血清HE4 TK1 CA199联合检测对卵巢癌的诊断价值

Diagnostic Value of Combined Detection of Serum HE4 TK1 and CA199 for Ovarian Cancer

目的:探讨血清人附睾蛋白4(HE4)、细胞质胸苷激酶(TK1)、糖类抗原199(CA199)联合检测对卵巢癌的诊断价值。方法:选取2016年3月至2018年3月我院妇科收治的124例拟行手术治疗的盆腔肿物患者为研究对象。根据术后病理检查结果将患者分为卵巢癌组(n=64)和卵巢良性疾病组(n=60),另随机选择同时间在本院进行体检的66例健康女性为对照组。比较3组受试者血清HE4、TK1、CA199水平差异,采用受试者工作特征曲线评估3项指标单项检测及联合检测的诊断价值[灵敏度、特异度、曲线下面积(AUC)]。结果:卵巢癌组血清HE4、TK1、CA199水平和单项指标阳性率均高于卵巢良性疾病组和对照组(P<0.05),卵巢良性疾病组血清HE4、TK1、CA199水平和单项指标阳性率均高于对照组(P<0.05);3项指标联合检测诊断卵巢癌灵敏度和AUC均高于单项检测(P<0.05),特异度与单项检测比较差异无统计学意义(P>0.05)。结论:血清HE4、TK1、CA199表达在卵巢癌、卵巢良性疾病患者以及健康人群中不同,可作为诊断卵巢癌的敏感指标,且3项指标联合检测可提高检测的诊断准确性。

Objective:To explore the diagnostic value of combined detection of serum human epididymis protein 4(HE4),cytoplasmic thymidine kinase(TK1)and carbohydrate antigen 199(CA199)for ovarian cancer.Methods:124 cases of patients with pelvic tumors who were undergoing surgical treatment in our hospital from March 2016 to March 2018 were selected for the study.According to the results of postoperative pathological examination,the patients were divided into ovarian cancer group(n=64)and benign ovarian disease group(n=60).And another 66 healthy women who were for physical examination at the same time were randomly selected as control group.The levels of serum HE4,TK1 and CA199 were compared among the three groups.The receiver operating characteristic curve was used to evaluate the diagnostic value[sensitivity,specificity,and area under curve(AUC)]of single index detection and combined detection of the three indexes.Results:The levels of serum HE4,TK1 and CA199 and positive rate of each single index in ovarian cancer group were higher than those in benign ovarian disease group and control group(P<0.05),and the levels of serum HE4,TK1 and CA199 and positive rate of each single index in benign ovarian disease group were higher than those in control group(P<0.05).The sensitivity and AUC of combined detection of the three indexes for ovarian cancer were higher than those of single index detection(P<0.05),and there was no significant difference in the specificity compared with that of single index detection(P>0.05).Conclusions:The expression levels of serum HE4,TK1 and CA199 are different in patients with ovarian cancer,patients with benign ovarian disease and healthy people.They can be used as sensitive indicators for ovarian cancer diagnosis,and combined detection of the three indexes can improve the diagnostic accuracy.