结肠癌肝转移患者临床病理因素对预后的影响

The influence of clinicopathologic parameters on prognosis of liver metastasis from colon cancer

目的:探讨结肠癌肝转移患者行手术治疗的效果以及患者的预后影响因素。方法:选取2010年2月至2015年1月5年间收治的结肠癌肝转移患者为研究对象,所有患者均进行手术治疗,治疗后对患者进行随访调查,观察随访1年、3年间患者的生存率,并且通过单因素分析影响患者预后的相关因素。结果:在120例结肠癌肝转移中,行单纯原发灶肿瘤切除患者1年、3年的生存率为47.87%、11.70%,行原发灶与肝转移灶均切除的患者1年、3年的生存率分别为65.38%、46.15%;单因素分析结果显示,肿瘤分化程度、CEA、肝转移灶切除、介入治疗、全身化疗是影响患者生存率的关键因素。结论:对于结肠癌肝转移患者而言,应尽快的采取手术根治的方法进行治疗,同时后续可采取介入治疗、全身化疗等方法来延长患者的生存周期。

Objective:To investigate the effect ofclinicopathologic parameters on prognosis of liver metastasis from colon cancer.Methods:Patients with colorectal cancer liver metastases from February 2010 to January 2015 were enrolled in this study.All patients underwent surgical treatment.The patients were followed up for 1 year and 3 years.Survival time and the univariate analysis were used to check the prognosis of patients related factors.Results:The 1-year survival rate and 3-year survival rate of patients with primary tumor resection was 47.87%and 11.70%respectively.However,The 1-year survival rate and 3-year survival rate of patientsundergoing primary and liver metastasis tumor resection was 65.38%and 46.15%.The results show that the degree of tumor differentiation,CEA,liver resection,interventional therapy and systemic chemotherapy are important factors forprognosis of patients.Conclusion:Patients with liver metastases of colon cancer should be treated with radical surgery as soon as possible,following with intervention therapy,systemic chemotherapy and other methods to promote the survival time.