自拟清肝利湿汤治疗宫颈癌化疗患者的临床疗效

Clinical Efficacy of Self-made Qinggan Lishi Decoction in the treatment of Patients with Cervical Cancer Chemotherapy

目的:研究自拟清肝利湿汤治疗宫颈癌化疗患者的临床疗效。方法:将2016年1月至2017年7月我院收治的86例宫颈癌化疗患者随机分为对照组(43例)和观察组(43例),对照组给予紫杉醇/伊立替康化疗方案,观察组在对照组的基础上给予自拟清肝利湿汤,均治疗6周后评估分析两组患者肿瘤直径、化疗所需时间、治疗效果、血清肿瘤标志物水平、免疫功能、生活质量及不良反应。结果:观察组治疗后肿瘤直径明显缩小,治疗总有效率为81.39%,高于对照组的72.09%(P<0.05)。观察组治疗后血清中糖链抗原125(CA125)、鳞状上皮癌相关抗原(SCCA)、癌胚抗原(CEA)水平显著下降(P<0.05);观察组血液中免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)水平、血液中CD3+、CD4+细胞比例、CD4+/CD8+比值明显增大(P<0.05);观察组治疗后SF-36评分均显著高于对照组(P<0.05),Ⅱ~Ⅲ级不良反应发生率明显低于对照组(P<0.05)。观察组治疗1年内局部复发率、远处转移率为4.65%、2.33%,低于对照组的11.63%、4.65%(P<0.05)。结论:自拟清肝利湿汤能够有效提高宫颈癌化疗患者的临床治疗效果。

Objective:To study the clinical efficacy of self-made Qinggan Lishi decoction in the treatment of patients with cervical cancer chemotherapy.Methods:86 patients with cervical cancer chemotherapy who were admitted to our hospital from January 2016 to July 2017 were randomly divided into control group(43 cases)and observation group(43 cases).Control group was given paclitaxel/irinotecan chemotherapy regimen,and observation group was given self-made Qinggan Lishi decoction on the basis of control group.After 6 w of treatment,the tumor diameter,time required for chemotherapy,treatment effects,serum tumor markers levels,immune function,quality of life and adverse reactions were evaluated and analyzed in the two groups.Results:The tumor diameter in observation group after treatment was significantly reduced,and the total effective rate of treatment was higher than that in control group(81.39%vs 72.09%)(P<0.05).The serum levels of carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCCA)and carcinoembryonic antigen(CEA)were significantly decreased in observation group after treatment(P<0.05).The levels of immunoglobulin G((IgG),immunoglobulin M(IgM)and immunoglobulin A(IgA),blood CD3+and CD4+cell ratios and CD4+/CD8+ratio in the blood were increased significantly in observation group(P<0.05).The SF-36 scores in observation group after treatment were significantly higher than those in control group(P<0.05),and the incidence rate of adverse reactions of gradeⅡ~Ⅲwas significantly lower than that in control group(P<0.05).The local recurrence rate and distant metastasis rate within 1 year of treatment were 4.65%and 2.33%in observation group,which were lower than those in control group with 11.63%and 4.65%(P<0.05).Conclusions:Self-made Qinggan Lishi decoction can effectively improve the clinical treatment effects of patients with cervical cancer chemotherapy.