分泌型IgA应用上呼吸道感染患儿对炎症反应和免疫功能指标的影响

Effects of secretory IgA on the inflammatory response and immune function indicators in children with upper respiratory tract infection

目的:探讨分泌型IgA应用上呼吸道感染患儿对炎症反应和免疫功能指标的影响。方法:收集在本院接受治疗的反复发作上呼吸道感染患儿80例进行回顾性分析,分为接受常规抗感染治疗的对照组43例、接受分泌型IgA联合常规抗感染治疗的分泌型IgA组37例。对比两组治疗前、治疗7d后血清炎症因子、免疫球蛋白含量及外周血Th1/Th2免疫应答指标水平的差异。结果:治疗前,两组血清炎症因子、免疫球蛋白含量及外周血Th1/Th2免疫应答指标水平比较,差异无统计学意义(P>0.05)。治疗7d,分泌型IgA组血清中炎症因子肿瘤坏死因子α(TNF-α)、白介素-2(IL-2)、白介素-18(IL-18)的含量低于对照组(P<0.05),血清中免疫球蛋白IgE的含量低于对照组,IgG2、IgG4的含量高于对照组(P<0.05),外周血中Th1细胞的分布比例及Th1/Th2比值高于对照组,Th2细胞分布比例低于对照组(P<0.05)。结论:反复上呼吸道感染患儿在常规抗感染药物治疗同时加入分泌型IgA进行联合治疗,可进一步抑制机体炎症反应并均衡免疫应答功能。

Objective:To investigate the effects of secretory IgA on the inflammatory response and immune function indicators in children with upper respiratory tract infection.Methods:80 children with recurrent upper respiratory tract infection who received treatment in our hospital between September 2017 and September 2018 were retrospectively analyzed,and divided into the control group(n=43)receiving conventional anti-infective drug therapy,and the sIgA group(n=37)receiving secretory IgA combined with conventional anti-infective drug therapy according to the treatment regimen.The differences in serum contents of inflammatory cytokines and immunoglobulins as well as peripheral blood levels of Th1/Th2 immune response indexes were compared between the two groups before the treatment and after 7 d of treatment.Results:Before the treatment,there were no significant differences in serum contents of inflammatory cytokines and immunoglobulins as well as peripheral blood levels of Th1/Th2 immune response indexes between the two groups.After 7 d of treatment,serum inflammatory cytokines tumor necrosis factor-a(TNF-a),interleukin-2(IL-2),interleukin-18(IL-18)contents of the sIgA group were lower than those of the control group;serum immunoglobulin IgE content was lower than that of the control group,while IgG2 and IgG4 contents were higher than those of the control group;peripheral blood Th1 cell distribution proportion and Th1/Th2 ratio were higher than those of the control group,while Th2 cell distribution proportion was lower than that of the control group.Conclusion:Conventional anti-infective drugs combined with secretory IgA can further inhibit the inflammatory response and balance the immune response in children with recurrent upper respiratory tract infection.