多层螺旋CT灌注技术对胰腺癌患者五例化疗评估

Value of multi-slice spiral CT perfusion in evaluating the efficacy of chemotherapy for five pancreatic cancer patients

目的评估多层螺旋CT灌注技术对胰腺癌化疗疗效的价值。方法选择2017年2月至2018年2月在我院化疗的5例胰腺癌患者进行研究,使用CT灌注成像作影像学随诊,评估患者的化疗效果。结果随访前后发现患者的肿瘤最大直径、视觉模拟评分(VAS)评分、卡氏(KPS)评分均无明显变化,但糖类抗原(CA19)-9有所升高,VAS评分、KPS评分、CA19-9变化等对实体瘤的疗效评价并无实际影响。化疗后,正常组织的BF值均有所下降,肿瘤组织BF值仅有2例明显下降,正常组织的BV值均有所降低,肿瘤组织血容量(BV)值有3例明显下降,2例轻度升高。正常组织的渗透性(PM)值略有升高,肿瘤组织PM值2例升高,3例降低。CT灌注参数化疗前后的变化能够准确反映胰腺癌病情变化。结论多层螺旋CT灌注技术应用于胰腺癌化疗疗效的评估,具有无创、快速、准确、客观的优势,为胰腺癌治疗提高有利的判断依据,具有重要的临床研究价值。

Objective To evaluate the value of multi-slice spiral CT perfusion in the treatment of pancreatic cancer.Methods From February 2017 to February 2018,5 patients with pancreatic cancer received chemotherapy in our hospital were studied.CT perfusion imaging was used as follow-up imaging to evaluate the effect of chemotherapy.Results There were no significant changes in tumor diameter,VAS score and KPS score before and after the follow-up.However,CA19-9 increased,and VAS score,KPS score and CA19-9 change had no practical effect on the evaluation of solid tumor.After chemotherapy,the BF value of normal tissues decreased,only 2 cases of tumor tissues decreased significantly,the BV value of normal tissues decreased,3 cases of tumor tissues decreased significantly,2 cases increased slightly.The PM value of the normal tissue increased slightly,and the PM value of tumor tissue increased in 2 cases and decreased in 3 cases.The changes of CT perfusion parameters before and after chemotherapy can accurately reflect the changes of pancreatic cancer.Conclusion Multi-slice spiral CT perfusion technique has the advantages of noninvasive,rapid,accurate and objective in evaluating the efficacy of chemotherapy for pancreatic cancer.It can improve the judgment basis for the treatment of pancreatic cancer and has important clinical research value.