乳腺癌肿瘤代谢异质性与p53基因表达和淋巴结转移相关性的研究

Correlation of intratumor metabolic heterogeneity with p53 expression and lymph node metastasis in breast cancer

目的:分析乳腺癌肿瘤代谢异质性与p53基因表达和乳腺癌淋巴结转移的关系。方法:选取接受18 F-FDG PET/CT检查的原发性乳腺癌患者34例,分别测定每例患者原发灶的肿瘤代谢异质因子(heterogeneity factor,HF),同时将HF与p53基因表达和淋巴结转移进行相关性分析,采用受试者工作特性曲线(area under receiver operating characteristic curve,ROC)分析HF对p53基因突变及淋巴结转移的诊断效能。结果:HF与乳腺癌p53基因表达呈弱相关性( P <0.05);HF与淋巴结转移无相关性( P >0.05)。结论:HF与乳腺癌p53基因表达具有相关性,HF对预测p53基因表达具有一定意义,然而,HF不能预测乳腺癌是否有淋巴结转移。

Objective:To evaluate the relationship between tumor heterogeneity factor and p53 and study the correlation of tumor heterogeneity factor and lymph node metastasis. Methods:Thirty four patients with primary breast cancer who underwent PET-CT examination were selected.The HF value of each patient was calculated by a computer.We analyzed the correlation between HF and p53 and studied HF and lymph node metastasis respectively. Results:There was a significant positive correlation between HF and p53 in breast cancer( P <0.05).However,HF was not associated with lymph node metastasis( P >0.05). Conclusion:HF is associated with p53 in breast cancer.So,computing HF helps the prediction of p53.HF can provide reference for tumor diagnosis,prognosis estimation and clinical guidance.However,HF cannot predict whether breast cancer patients have lymph node metastasis.