氨甲环酸对全髋关节置换术后隐性失血及深静脉血栓的影响

Influence of Tranexamic Acid on Hidden Blood Loss and Deep Venous Thrombosis after Total Hip Replacement

目的研究氨甲环酸对全髋关节置换术后隐性失血及深静脉血栓的影响。方法选择我院2015年10月至2018年5月收治的全髋关节置换术患者54例,根据药物使用情况平均分为两组。对照组采用生理盐水,研究组采用氨甲环酸,对比两组患者的血红蛋白、凝血指标与失血输血情况。结果术前,两组患者的血红蛋白水平、凝血指标比较无统计学差异(P>0.05)。术后1周,研究组的凝血指标均高于对照组(P <0.05);术后1 d、 3 d,研究组的血红蛋白水平均高于对照组,失血情况和输血情况均优于对照组(P均<0.05)。结论在全髋关节置换术中使用氨甲环酸,能够降低患者的失血量和输血量,有利于提高手术效果,值得临床应用。

Objective To study the influence of tranexamic acid on hidden blood loss and deep venous thrombosis after total hip replacement. Methods 54 cases of patients with total hip replacement admitted to our hospital from October 2015 to May 2018 were selected and equally divided into two groups according to the drug use. The control group was given normal saline, while the study group was given tranexamic acid. The hemoglobin, blood coagulation indicators, blood loss and blood transfusion were compared between the two groups.Results Before operation, no statistical difference was found in the hemoglobin level and blood coagulation indicators between the two groups(P >0.05). 1 week after operation, the blood coagulation indicators of the study group were higher than those of the control group(P<0.05). 1 d and 3 d after operation, the hemoglobin levels of the study group were higher than those of the control group, and the blood loss and blood transfusion were better than those of the control group(all P <0.05). Conclusions Tranexamic acid in total hip replacement can reduce the blood loss and blood transfusion, which is beneficial to improve the surgical effect and is worthy of clinical application.