泮托拉唑治疗非曲张静脉上消化道出血的临床效果观察

Observation on Clinical Effect of Pantoprazole in the Treatment of Non-Varicose Upper Gastrointestinal Bleeding

目的探讨泮托拉唑治疗非曲张静脉上消化道出血的临床效果。方法选取我院2016年1月至2018年12月收治的66例非曲张静脉上消化道出血患者,随机分为观察组和对照组各33例。两组均给予常规治疗,在此基础上对照组给予奥美拉唑钠治疗,观察组给予泮托拉唑治疗。观察两组的治疗效果及安全性。结果观察组的总有效率为96.97%,显著高于对照组的78.79%(P <0.05)。观察组的出血总量明显低于对照组,出血停止时间及住院时间明显短于对照组(P均<0.05)。观察组治疗期间的不良反应发生率为6.06%,与对照组的9.09%比较差异无统计学意义(P>0.05)。结论泮托拉唑治疗非曲张静脉上消化道出血,可显著改善患者的临床症状,且安全性高,值得推广。

Objective To explore the clinical effect of pantoprazole in the treatment of non-varicose upper gastrointestinal bleeding.Methods 66 cases of patients with non-varicose upper gastrointestinal bleeding admitted to our hospital from January 2016 to December2018 were selected and randomly divided into observation group and control group, with 33 cases in each group. Both groups were given routine treatment. On this basis, the control group was treated with omeprazole sodium, while the observation group was treated with pantoprazole. Results The total effective rate of the observation group was 96.97%, significantly higher than 78.79% of the control group(P<0.05). The total blood loss of the observation group was significantly lower than that of the control group, and the bleeding cessation time and hospitalization time were significantly shorter than those of the control group, with statistical differences(P <0.05). The incidence of adverse reactions during treatment of the observation group was 6.06%, had no statistical difference with 9.09% of the control group(P>0.05). Conclusions Pantoprazole in the treatment of non-variceal upper gastrointestinal bleeding can significantly improve the clinical symptoms of patients with high safety, which is worthy of promotion.