沙利度胺联合柳氮磺吡啶对强直性脊柱炎患者炎性反应的影响

Influence of Thalidomide Combined with Sulfasalazine on Inflammatory Response in Patients with Ankylosing Spondylitis

目的探讨沙利度胺联合柳氮磺吡啶对强直性脊柱炎患者炎性反应的影响。方法选取2016年5月至2018年5月我院收治的强直性脊柱炎患者76例,随机分为对照组和观察组各38例。对照组给予柳氮磺吡啶治疗,观察组采用沙利度胺联合柳氮磺吡啶治疗,比较两组的治疗效果、炎性因子水平、脊柱活动度、骨密度。结果观察组的总有效率为94.74%,高于对照组的78.95%(P <0.05)。观察组治疗后的IL-6、 IL-23、 TNF-α水平均低于对照组,脊柱活动度、骨密度T值均高于对照组,差异均有统计学意义(P <0.05)。结论沙利度胺联合柳氮磺吡啶治疗强直性脊柱炎患者,可有效提高治疗效果,降低炎性因子水平,改善脊柱活动度及骨密度,可行性高。

Objective To explore the influence of thalidomide combined with sulfasalazine on inflammatory response in patients with ankylosing spondylitis. Methods 76 cases of patients with ankylosing spondylitis admitted to our hospital from May 2016 to May 2018 were selected and randomly divided into control group and observation group, with 38 cases in each group. The control group was treated with sulfasalazine, while the observation group was treated with thalidomide combined with sulfasalazine. The treatment effect, levels of inflammatory factors, spinal mobility and bone density were compared between the two groups. Results The total effective rate of the observation group was 94.74%, higher than 78.95% of the control group(P <0.05). After treatment, the IL-6, IL-23 and TNF-α levels of the observation group were lower than those of the control group, and the spinal mobility and bone density T value were higher than those of the control group(all P <0.05). Conclusions Thalidomide combined with sulfasalazine in the treatment of patients with ankylosing spondylitis can effectively improve the treatment effect, reduce the levels of inflammatory factors, and improve the spinal mobility and bone density,with high feasibility.