脑梗死出血转化发生的危险因素分析与研究

Analysis and Research on Risk Factors of Hemorrhagic Transformation in Cerebral Infarction

目的探讨脑梗死出血转化发生的危险因素.方法选取我院2017年9月-2018年12月收治的122例脑梗死患者作为研究对象,根据是否发生脑梗死出血转化将研究对象分为转化组和未转化组,收集两组患者的详细资料,对脑梗死出血转化的危险因素进行单因素分析和多因素分析.结果单因素分析结果显示:梗死部位、梗死面积、房颤、溶栓治疗、同型半胱氨酸水平、神经功能缺损程度(NHISS评分)、基础疾病均为脑梗死出血转化发生的危险因素(P<0.05).多因素分析结果显示:房颤、大面积梗死、皮层梗死、高同型半胱氨酸为脑梗死出血转化发生的独立性危险因素(P<0.05).结论能够导致脑梗死出血转化发生的危险因素较多,除脑梗死相关的因素外,还包括心脏状态、生化指标水平变化等,建议临床加强分析,为预防措施的制定提供更多客观参考依据.

Objective To investigate the risk factors of hemorrhagic transformation in cerebral infarction. Methods A total of 122 patients with cerebral infarction admitted to our hospital from September 2017 to December 2018 were enrolled. The subjects were divided into transformed group and untransformed group according to whether or not cerebral infarction hemorrhage occurred. The details of the two groups were collected. Data were used to analyze the risk factors for cerebral infarction hemorrhage by univariate analysis and multivariate analysis. Results Univariate analysis showed that infarct location, infarct size, atrial fibrillation, thrombolytic therapy, homocysteine level, neurological deficit (NHISS score), underlying disease were risk factors for cerebral infarction hemorrhage (P < 0.05), while multivariate analysis showed that atrial fibrillation, large-area infarction, cortical infarction and homocysteine were independent risk factors for hemorrhagic transformation in cerebral infarction (P < 0.05). Conclusion There are many risk factors for hemorrhage transformation in cerebral infarction. In addition to the factors related to cerebral infarction, it also includes changes in cardiac status and biochemical indicators. It is recommended to strengthen clinical analysis to provide more objective reference for the development of preventive measures.