妊娠期重症肌无力对母儿的影响及诊治

Diagnosis and treatment of myasthenia gravis during pregnancy and the effect on mother and child

重症肌无力(myasthenia gravis,MG)常发生在20~45岁的育龄女性,病情变化常难以预测。妊娠合并MG轻症者可考虑继续妊娠,重症者应终止妊娠。妊娠期间应加强监护,维持病情的稳定,确保母亲及胎儿的安全。妊娠期间用药是安全的,临床常用的药物有抗胆碱酯酶药、免疫抑制剂和免疫球蛋白等。MG不是剖宫产的指征,可经阴道自然分娩。新生儿可能会出现一过性的肌无力,但往往是暂时的。

Myasthenia gravis (MG) often occurs in women of childbearing age between 20 to 45 years,and changes in MG′s condition during pregnancy are often difficult to predict.Continue pregnancy may be considered for pregnancy with MG mild cases,and severe cases should be terminated.During pregnancy,supervision should be strengthened to maintain the stability of the condition and ensure the safety of the mother and the fetus.It is safe to take anti-cholinesterase drugs,immunosuppressant and immunoglobulins for MG patients during pregnancy.In addition,MG is not an indication for cesarean section;it can be delivered naturally through the vagina.Newborns may have transient muscle weakness,but it is often temporary.