Toll样受体4促进宫颈上皮内瘤变进展的机制研究

Mechanism of TLR4 promoting the progression of cervical intraepithelial neoplasia

目的探讨Toll样受体4(TLR4)在正常宫颈组织、宫颈上皮内瘤变(CIN)组织、宫颈癌中的表达情况,分析TLR4与CIN及宫颈癌的相关性,并研究其对临床诊断的影响及评价。方法将2018年4月至12月期间来我院进行宫颈检查女性,随机选取正常宫颈组织6例,CIN17例以及宫颈癌7例,检测3组TLR4阳性表达情况,分析影响其表达的相关因素。结果TLR4在正常宫颈组织、CIN以及宫颈癌组织中的表达强度呈递增升高,差异有统计学意义(P<0.05);TLR4的表达与患者年龄及细胞分化程度无明显关系(P>0.05);与肿瘤分期和人乳头瘤病毒(HPV)感染具有明显的相关性,差异有统计学意义(P<0.05)。结论TLR4在正常宫颈组织、CIN、宫颈癌组织中的表达逐渐升高,TLR4的表达与HPV感染、CIN及宫颈癌发病具有相关性,能够为临床疾病的诊疗情况提供较优的参考价值。

Objective To analyze the expression of Toll-like receptor 4(TLR4)in normal cervical tissues,cervical intraepithelial neoplasia(CIN)and cervical cancer,and to analyze the correlation between TLR4 and CIN and cervical cancer,and to study its impact on clinical diagnosis and the evaluation.Methods Six cases of normal cervical tissue,17 cases of CIN and 7 cases of cervical cancer were randomly selected from the women who received cervical examination in our hospital from April 2018 to December 2018.The positive expression of TLR4 in the three groups was examined,and the relevant factors that affecting its expression were analyzed.Results The expression intensity of TLR4 in normal cervical tissues,CIN and cervical cancer tissues was increased gradually,and the difference was statistically significant(P<0.05).The expression of TLR4 was not correlated with the age and cell differentiation of patients(P>0.05),and there was a significant correlation between TLR4 expression and tumor expression and HPV infection,and the difference was statistically significant(P<0.05).Conclusions The expression of TLR4 in normal cervical tissues,CIN and cervical cancer tissues is gradually increased.The expression of TLR4 is associated with HPV infection,CIN and cervical cancer,and it can provide a good reference value for the diagnosis and treatment of clinical diseases.