膜联蛋白A2在输卵管癌中的表达及临床意义

The expression and clinical significance of annexin A2 in fallopian tube carcinoma

目的:检测膜联蛋白A2(annexinA2,ANXA2)在输卵管癌组织中的表达情况,并探讨膜联蛋白A2的表达与输卵管癌患者临床病理参数的关系及其预后的相关性。方法:采用免疫组化SP法检测62例输卵管癌组织和25例正常输卵管组织中ANXA2的表达情况,分析其与输卵管癌患者临床病理参数及疾病预后的关系。结果:ANXA2主要定位于细胞膜,亦在细胞质着色,ANXA2在输卵管癌中的高阳性表达率为50%,明显低于正常输卵管组织(96%),P<0.01;ANXA2的高阳性表达率随着输卵管癌分化程度降低而降低(P<0.05);生存曲线分析显示ANXA2阴性表达的输卵管癌患者总体生存率缩短(P<0.05)。结论:ANXA2在输卵管癌组织中表达降低,且与输卵管癌不良预后有关,可用于临床监测输卵管癌患者病情变化。

Objective:To detect the expression of annexin A2(ANXA2)in fallopian tube carcinoma and to further investigate the relationship between annexin A2 and clinicopathological parameters of fallopian tube carcinoma and its prognosis.Methods:The expression of ANXA2 in 62 cases of fallopian tube carcinoma and 25 cases of normal fallopian tube tissues were measured by immunohistochemistry.The relationship between the expression of ANXA2 and clinicopathological parameters and prognosis of patients with fallopian tube cancer were also analyzed.Results:ANXA2 was mainly expressed in the cell membrane,also stained in cytoplasm.The high positive expression rate of ANXA2 in fallopian tube carcinoma was 50%,which was significantly lower than that of normal fallopian tube tissue(96%),P<0.01.With the degree of differentiation decreased,the high positive expression rate of ANXA2 was also decreased(P<0.05).The analysis survival curve showed that the overall survival rate of patients with fallopian tube carcinoma with negative ANXA2 expression was shortened(P<0.05).Conclusion:ANXA2 expression is decreased in fallopian tube carcinoma and is associated with poor prognosis of fallopian tube carcinoma.It can be used for clinical monitoring of patients with fallopian tube carcinoma.