促红细胞生成素治疗新生儿脑病的临床研究

Clinical Effect of Erythropoietin on Neonatal Encephalopathy

目的分析促红细胞生成素对新生儿脑病的临床治疗效果。方法择取本院100例HIE患儿作为研究对象,将其随机分为研究组与对照组。另外择取50名正常健康新生儿作为正常组。给予对照组进行常规治疗,研究组在上述基础上,进行EPO注射治疗,观察患儿出生7、14、28天后的NBNA评分及患儿出生3、6个月后的MDI、PDI评分。结果(1)研究组患儿出生7、14、28天后的NBNA评分高于对照组,低于正常组;对照组患儿出生7、14、28天后的NBNA评分均低于正常组;(2)研究组中3个月及6个月患儿的MDI和PDI均高于对照组,低于正常组;对照组中3个月及6个月患儿的MDI和PDI均低于正常组。结论对HIE患者进行EPO的治疗效果较好。

Objective To analyze the clinical effect of erythropoietin on neonatal encephalopathy.Methods 100 cases of HIE in our hospital were selected as the study objects and they were randomly divided into study group and control group.Another 50 cases of normal healthy newborns were selected as normal group.The control group was given routine treatment.The study group was given EPO injection treatment on the basis of the above.The NBNA score after 7,14,28 days of birth and the MDI and PDI scores after 3,6 months of birth were observed.Results(1)The NBNA score of the study group was higher than that of the control group 7,14 and 28 days after birth,but lower than that of the normal group.The NBNA score of the control group was lower than that of the normal group 7,14 and 28 days after birth.(2)MDI and PDI in the study group were higher than those in the control group at 3 and 6 months,lower than those in the normal group.In the control group,MDI and PDI were lower than those in the normal group at 3 and 6 months.Conclusion EPO treatment for HIE patients is effective.