低氧训练调控microRNA表达的研究现状

近年来,微RNA(miRNA,microRNA)被发现是一类与RNA家族基因表达调控密切相关的小分子。miRNA是一类非编码的单链RNA分子,内源性基因编码长度为21-25个核苷酸,miRNA在许多生物过程中起着不可或缺的作用,包括免疫反应、发育、干细胞分化、脂肪细胞分化和脂质代谢。低氧及低氧训练可以调控多种miRNA的表达,不仅在许多组织细胞中得到了证明,而且也参与了脂肪细胞分化、脂代谢等多种生物过程调控。为了促进低氧和低氧训练调控miRNA表达相关方面的研究,本文通过综述miRNA的合成与功能、运动对miRNA的影响,探讨低氧和低氧训练与miRNA的关系,以期促进miRNA与心肌梗死,缺血低氧损伤、肿瘤、血管发生等之间的联系,为肥胖机体减重降脂以及脂代谢相关疾病的干预提供研究思路。

In recent years,microRNA(miRNA),a class of small molecules closely related to gene expression regulation,has been found in the RNA family.Micrornas are a class of non-coding single-stranded RNA molecules,endogenous gene encoding length is 2-25 nucleotides,the miRNA plays an indispensable role in many biological processes,including immune response,development,differentiation of stem cells,fat cells and lipid metabolism,transcription factors.Hypoxia and hypoxia training can regulate the expression of a variety of mirnas,which has not only been proved in many tissue cells,but also participated in the regulation of adipocyte differentiation,lipid metabolism and other biological processes.In order to promote hypoxia and hypoxia training control the miRNA expression related research,this article through the synthesis of micrornas and function,the influence of exercise on the miRNA,hypoxia and hypoxia training and the relationship of micrornas,in order to promote the miRNA and myocardial infarction,ischemia hypoxia injury,the connection between the tumor and angiogenesis,lipid and body weight loss for obesity intervention provides research train of thought of the lipid metabolism related diseases.