红细胞比容、血清C反应蛋白及IL-6与急性胰腺炎严重程度的相关性分析

Analysis on the Correlations of Hematocrit, Serum C-Reactive Protein and IL-6 with the Severity of Acute Pancreatitis

目的分析红细胞比容(HCT)、血清C反应蛋白(CRP)及白介素-6(IL-6)与急性胰腺炎严重程度的相关性。方法60例急性胰腺炎患者根据疾病严重程度分为轻症急性胰腺炎(MAP)组及重症急性胰腺炎(SAP)组各30例;另选取同期健康人群的30例作为对照组。比较三组的HCT、CRP及IL-6水平,分析HCT、CRP及IL-6与急性胰腺炎严重程度的相关性。结果SAP组的HCT、CRP及IL-6水平均显著高于MAP组和对照组,MAP组的HCT、CRP及IL-6水平均显著高于对照组,差异均具有统计学意义(P<0.05)。Pearson相关性分析显示,HCT、CRP及IL-6与急性胰腺炎严重程度均呈正相关(r=0.763、0.810、0.669,P<0.05)。结论HCT、CRP及IL-6与急性胰腺炎的严重程度均有密切相关性,具有较高的诊断价值。

Objective To analyze the correlations of hematocrit(HCT), serum C-reactive protein(CRP) and interleukin-6(IL-6) with the severity of acute pancreatitis(AP). Methods 60 AP patients were divided into the mild AP(MAP) group and severe AP(SAP) group according to the severity of the disease, with 30 cases in each group. 30 cases of healthy subjects at the same period were selected as the control group. The levels of HCT, CRP and IL-6 were compared among three groups, and the correlations of HCT, CRP and IL-6 with the severity of AP were analyzed. Results The levels of HCT, CRP and IL-6 of SAP group were significantly higher than those of MAP group and control group, and the levels of HCT, CRP and IL-6 of MAP group were significantly higher than those of control group(P <0.05).Pearson correlation analysis showed that HCT, CRP and IL-6 were positively correlated with the severity of AP(r = 0.763, 0.810, 0.669;P<0.05). Conclusions HCT, CRP and IL-6 are closely related to the severity of acute pancreatitis and have high diagnostic value.