维生素A缺乏、炎性因子和小儿反复呼吸道感染的相关性分析

Analysis on the Correlations Among Vitamin A Deficiency, Inflammatory Factors and Recurrent Respiratory Infection in Children

目的探讨维生素A缺乏、炎性因子和小儿反复呼吸道感染(RRI)的相关性。方法纳入我院2017年12月至2018年12月收治的呼吸道感染患儿68例为观察组,同期健康儿童60例为对照组。检测维生素A水平,比较两组的维生素A缺乏发生率;比较两组的Ig G、IL-1、淋巴计数水平。结果观察组的维生素A缺乏发生率为30.88%,显著高于对照组的10.00%(P<0.05)。观察组的IgG、IL-1、淋巴计数、维生素A水平均显著低于对照组(P<0.05)。Pearson相关性分析显示,维生素A水平与IgG(r=0.512,P=0.001)、IL-1(r=0.408,P=0.000)、淋巴计数(r=0.594,P=0.002)呈现显著的正相关;RRI的发生与IgG(r=-0.352,P=0.021)、IL-1(r=-0.468,P=0.002)、淋巴计数(r=-0.684,P=0.008)呈现显著的负相关。结论RRI患儿的维生素A水平较正常儿童低,炎性因子水平和维生素A呈现正相关。

Objective To investigate the correlations among vitamin A deficiency, inflammatory factors and recurrent respiratory infection(RRI) in children. Methods 68 children with RRI admitted to our hospital from December 2017 to December 2018 were enrolled as observation group, and 60 healthy children at the same period were enrolled as control group. The level of vitamin A was measured, to compare the incidences of vitamin A deficiency of two groups. The levels of Ig G, IL-1 and lymph count of the two groups were compared.Results The incidence of vitamin A deficiency in the observation group was 30.88%, significantly higher than 10.00% in the control group(P <0.05). The levels of Ig G, IL-1, lymph count and vitamin A in the observation group were significantly lower than those in the control group(P <0.05). Pearson correlation analysis showed that vitamin A level was positively correlated with Ig G(r = 0.512, P = 0.001), IL-1(r =0.408, P = 0.000) and lymph count(r = 0.594, P = 0.002). The incidence of RRI was negatively correlated with Ig G(r =-0.352, P = 0.021),IL-1(r =-0.468, P = 0.002) and lymph count(r =-0.684, P = 0.008). Conclusions RRI children has lower level of vitamin A than normal children, and the levels of inflammatory factors are positively correlated with vitamin A.