地塞米松与泼尼松治疗亚急性甲状腺炎的临床疗效观察

Observation on the Clinical Efficacy of Dexamethasone and Prednisone in the Treatment of Subacute Thyroiditis

目的观察地塞米松与泼尼松治疗亚急性甲状腺炎的临床疗效。方法选取120例亚急性甲状腺炎患者随机分为观察组和对照组各60例,对照组患者给予醋酸泼尼松治疗,观察组患者给予局部注射地塞米松治疗,比较两组患者的治疗效果。结果观察组患者的甲状腺肿大消失时间、疼痛消失时间及退热时间均显著短于对照组(P<0.05)。观察组的治疗总有效率为93.33%,显著高于对照组的80.00%(P<0.05)。治疗结束后,观察组患者的ESR、FT3及FT4水平均显著低于对照组,TSH水平显著高于对照组(P<0.05)。随访期间,观察组的复发率为1.67%,显著低于对照组的11.67%(P<0.05)。结论与泼尼松相比,地塞米松治疗亚急性甲状腺炎的疗效更优,复发率更低,值得临床推广。

Objective To observe the clinical efficacy of dexamethasone and prednisone in the treatment of subacute thyroiditis(SAT). Methods 120 cases of SAT patients were selected and randomly divided into two groups, with 60 cases in each group. The control group was treated with prednisone acetate, and the observation group was treated with local injection of dexamethasone. The curative effects of two groups were compared. Results The disappearance time of goiter, pain and fever of observation group were significantly shorter than those of control group(P <0.05). The total effective rate of treatment of observation group was 93.33%, significantly higher than 80.00% of control group(P <0.05). After treatment, the levels of ESR, FT3 and FT4 of observation group were significantly lower than those of control group, and the level of TSH was significantly higher than that of control group(P <0.05). During the follow-up period, the recurrence rate of observation group was 1.67%, significantly lower than 11.67% of control group(P <0.05). Conclusions Compared with prednisone,dexamethasone has better efficacy and lower recurrence rate in the treatment of SAT, which is worthy of clinical promotion.