分子印迹模拟酶的制备与应用研究

Preparation and Application of Enzyme-Mimics Based on Molecular Imprinting

分子印迹模拟酶是应用分子印迹技术合成的对目标分子具有特异性催化活性的聚合物,具有良好的化学和物理稳定性、结构预定性以及实用性。本文主要介绍了分子印迹模拟酶的构建策略,包括印迹过渡态类似物、印迹底物或底物类似物和其他构建途径;探讨了分子印迹模拟酶的制备方法,总结了分子印迹模拟酶在催化反应方面的应用,涉及有机合成催化、食品安全危害物分解、环境污染物降解和临床医学检验等。

Molecular imprinting mimic enzyme is a man-made polymer which has the specific catalytic activity for the target molecule by using molecular imprinting technology. It also shows good chemical and physical stability,structural predetermination and practicality. This paper mainly presents the construction strategy of the molecular imprinting mimic enzyme: transition state analogs imprinting,substrate or structural analogs imprinting and other construction approaches.The recent research progress in the preparation method was reviewed in this paper. The catalytic reactions with the enzyme mimics which relate to the catalysis for organic synthesis,decomposition of hazardous substances for food safety,degradation of environmental pollutants and examination in clinical medicine etc were summarized.