哺乳动物晶状体再生的研究进展

Advances and clinical application of lens regeneration in mammal

晶状体再生是白内障患者恢复可调节视力、拥有优良视觉质量的理想策略.但哺乳动物晶状体再生速度慢且不完全,无法实现功能性晶状体再生.低等两栖动物(如蝾螈)强大的晶状体再生能力,为哺乳动物晶状体再生提供了动力.目前,哺乳动物晶状体再生主要的形式是以囊袋为支架由晶状体上皮细胞分化而成.近年来,随着干细胞技术、组织工程技术和生物材料的不断发展,哺乳动物晶状体再生研究取得了较大进展.本文拟总结晶状体的正常发育过程,回顾国内外晶状体再生的研究成果,探讨目前再生医学相关的新技术、新方法应用到晶状体再生的可能性,希望为功能性晶状体快速且相对完全再生研究提供参考.

Regeneration of the lens is an ideal strategy for cataract patients to restore their adjustable vision and to acquire excellent visual quality.However,mammalian lens regeneration is slow and incomplete,and functional lens regeneration cannot be achieved.The ability of lower amphibians(such as newts)to regenerate the lens provides the impetus for research on the regeneration of the lens of mammal.At present,the main form of mammalian lens regeneration is the differentiation of lens epithelial cells by capsular bag as a scaffold.In recent years,the continuous development of stem cell technology,tissue engineering and biological materials have made great progress in lens regeneration.This article describes the processes in the normal development of the lens,and reviews the research results of lens regeneration at home and abroad,and discusses the possibility of the new techniques and methods related to regenerative medicine applied to lens regeneration.It is hoped to help in the realization of rapid and complete regeneration of functional lens.