2015～2017年滕州市疑似预防接种异常反应监测分析

Analysis on surveillance data of adverse events following immunization,Tengzhou city,2015-2017

目的了解滕州市疑似预防接种异常反应(AEFI)发生情况和特征,评价AEFI监测工作质量和预防接种安全性。方法通过滕州市AEFI信息管理系统收集报告的2015~2017年疑似预防接种异常反应个案信息,采用描述性流行病学方法进行统计分析。结果 2015~2017年滕州市共报告疫苗接种后AEFI个案1 259例,报告发生率分别为57.57/10万、72.98/10万、76.42/10万(P<0.05),异常反应6例(0.48%)、一般反应1 249例(99.20%)、偶合症4例(0.32%)。一类疫苗和二类疫苗报告发生率分别为65.15/10万和100.17/10万(P<0.01)。7月是AEFI发生的高峰期(186例)。1岁以下儿童发生AEFI例数最多(755例、占59.97%)。92.69%(1 167例)的AEFI发生在接种疫苗后24 h内。结论滕州市疫苗安全性在预期范围内,异常反应发生率较低,以发热、红肿、硬结为主。

Objective To understand the incidence and characteristics of adverse events following immunization (AEFI) in Tengzhou city,so as to evaluate the quality of surveillance work and the safety of vaccines. Methods Data on AEFI reported in Tengzhou city during 2015-2017 was collected from National Immunization Program In formation Management System. Descriptive epidemiological method was used to analyze the data. Results During 2015-2017,a total of 1 259 AEFI were reported in Tengzhou city,the incidence was 57. 57/10^5 ,72. 98/10^5 and 76. 42/10^5 respectively, with statistically significant differences( P<0. 05). Of all the AEFI reported, 6 cases (0.48%) were rare reactions, 1 249 cases (99. 20%) were common reactions,and 4 cases (0. 32%) were coincidence. The incidence of AEFI was 65. 15/10^5 in the type of category Ⅰ vaccines and 100. 17/10^5 in the type of category Ⅱ vaccines( P<0. 01). Most AEFI cases were reported in July (186 cases). The AEFI cases mainly occurred in the small children less than 1 year old (755 cases, 59. 97%). 92. 69%(1167 cases) of the reported cases occurred within 1 day after the vaccination. Conclusion The reported incidences of AEFI for all vaccines are not higher than the expected. The occurrence rate of rare reactions is low. The symptoms for common reactions of the AEFI are mainly fever,local swelling and local indurations.