长链非编码RNA在特发性肺纤维化中的研究进展

Recent advances of long non-coding RNA in idiopathic pulmonary fibrosis

特发性肺纤维化是一种慢性进行性纤维化间质性肺炎,原因不明,主要发生在老年人中,仅限于肺部。目前研究显示氧化损伤、上皮-间质转化、端粒缩短、表观遗传学改变等在特发性肺纤维化的发生、发展中发挥重要作用。长链非编码RNA通过调节mRNA转录或翻译参与特发性肺纤维化的生物学过程。本文就近年来长链非编码RNA在特发性肺纤维化中的研究进展作一综述。

Idiopathic pulmonary fibrosis is a chronic, progressive fibrotic interstitial pneumonia with unknown etiology, occurs mainly in older individuals and is limited to the lungs.Current studies have shown that oxidative damage, epithelial-mesenchymal transition, telomere shortening and epigenetic changes play important roles in the occurance and development of idiopathic pulmonary fibrosis.Long non-coding RNA is involved in idiopathic pulmonary fibrosis through regulating mRNA transcription or translation.This article reviews the advances of long non-coding RNA in idiopathic pulmonary fibrosis in recent years.