期刊文献+

基于支持向量机的供体剪接位点识别

Recognition of donor splice sites based on support vector machine
下载PDF
导出
摘要 剪接位点识别是基因识别中的关键环节。本文对待测样本采用0/1编码,以表征各位置上的碱基,并结合碱基二联体出现的频次,最后采用支持向量机(SVM)进行分类决策。HS3D数据集上的仿真结果显示,本方法获得的预测精度为92.84%。 splicing site recognition is the key link in gene recognition. In this paper, the test samples are encoded with 0 / 1 encoding to represent the bases at each position, and the occurrence frequency of the base dimer is combined. Finally, support vector machine ( SVM) is adopted to make classification decisions. The simulation results on HS3D data set show that the prediction accuracy obtained by this method is 92. 84%.
作者 曾莹 Zeng Ying
出处 《数码设计》 2018年第12期82-82,共1页 Peak Data Science
基金 湖南农业大学东方科技学院2016年青年科学基金项目(16QNZ01):基于机器学习的分子序列信号位点识别研究.
关键词 剪接位点 基因识别 支持向量机(SVM) 0/1编码 splicing site splicing site Gene identification Support vector machines ( SVM) 0 / 1 coding
  • 相关文献

参考文献2

二级参考文献38

  • 1刘利,李前忠,樊国梁.低维输入空间的支持向量机识别人类剪接位点[J].生物物理学报,2008,24(1):49-56. 被引量:3
  • 2晋宏营,罗辽复,张利绒.核酸-蛋白质结合能在剪切位点识别中的应用[J].生物物理学报,2007,23(3):185-191. 被引量:3
  • 3Wang E T, Sandberg R, Luo S, et al.Altemative isoform regulation in human tissue transcriptomes[J].Nature,2008, 456(7221 ) :470-476.
  • 4Pan Q, Shai O,Lee L J,et al.Deep surveying of alterna- tive splicing complexity in the human transcriptome by high-throughput sequencing[J].Nat Genet, 2008,40 (12) : 1413-1415.
  • 5Faustino N A, Cooper T A.Pre-mRNA splicing and human disease[J].Genes & Development,2003,17(4):419-437.
  • 6Garcia-Blanco M A,Baraniak A P,Lasda E L.Alterna- tive splicing in disease and therapy[J].Nature Biotechnol- ogy, 2004,22 (5) : 535-546.
  • 7Wang G S, Cooper T A.Splicing in disease: disruption of the splicing code and the decoding machinery[J].Nature Reviews Genetics, 2007,8 (10) : 749-761.
  • 8Cooper T A, Wan L,Dreyfuss G.RNA and disease[J].Cell, 2009,136(4) : 777-793.
  • 9Wang Z,Burge C B.Splicing regulation:from a parts list of regulatory elements to an integrated splicing code[J]. RNA,2008,14(5) :802-813.
  • 10Ben-Gal I, Shani A, Gohr A, et al.Identification of tran- scription factor binding sites with variable-order bayes- ian networks[J].Bioinformatics, 2005,21 ( 11 ) : 2657-2666.

共引文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部