广西防城港市中年男性同型半胱氨酸与代谢综合征相关性分析

Relationship between serum homocysteine and metabolic syndrome in middle-aged men in Fangchenggang City

目的研究广西壮族自治区防城港市中年男性血清同型半胱氨酸(homocysteine,Hcy)与代谢综合征(Metabolic syndrome,MS)的相关性.方法研究对象为2009年9~12月防城港市随机抽样的4303名男性,采用回顾性分析方法收集代谢综合征及Hcy相关指标资料.运用多元线性回归方法和非条件Logistic回归方法进行分析.结果通过纳入排除标准,共484名受试者纳入研究.MS患者的Hcy平均水平高于非MS者[(16.81±5.74)μmol/L vs(15.40±4.00)μmol/L,P=0.028];并且MS患者的收缩压(r=0.161,P<0.001)、腰围(r=0.120,P=0.010)和总胆固醇(r=0.117,P=0.009)与Hcy呈正相关,但是高密度脂蛋白胆固醇与Hcy呈负相关(r=-0.092,P=0.047).Hcy与MS在校正年龄后,Hcy>16.56μmol/L是MS的危险因素[OR=1.904,95%CI(1.073,3.378)].结论Hcy>16.56μmol/L可能是MS的独立危险因素.

Objective To investigate the relationship between serum Hcy levels and MS in middle-aged men in Fangchenggang City,Guangxi.Methods The association of MS and Hcy levels were analysed in 4 303 men who participated in the examination survey population-based Fangchenggang city from Sep to Dec in 2009.Results 484 men were chosen in the study.The serum Hcy levels of MS was higher than that of non-MS([16.81±5.74)μmol/L vs(15.40±4.00)μmol/L,P=0.028].Systolic blood pressure(r=0.161,P 0.001),waist circumference(r=0.120,P=0.010)and total cholesterol(r=0.117,P=0.009)were positively correlated with Hcy,but high density lipoprotein cholesterol was negatively correlated with Hcy(r=-0.092,P=0.047).After adjustment for age,serum Hcy16.56μmol/L was a risk factor for MS[OR=1.904,95%CI(1.073,3.378)].Conclusion Serum Hcy16.56μmol/L may be an indeperdent riskfactor for MS.