老年高血压合并冠心病患者血压变异性与颈动脉斑块的关系研究

Study on the relationship between blood pressure variation and carotid artery plaque in elderly patients with hypertension and coronary heart disease

目的探讨老年高血压合并冠心病患者血压变异性与颈动脉斑块的关系.方法选取98例高血压合并冠心病患者的临床资料进行回顾性分析,经过颈动脉彩色多普勒超声检查,将所有患者分为无颈动脉斑块组33例与颈动脉斑块组65例,同时经冠状动脉造影将患者分为单支病变组56例和多支病变组42例.对所有患者均进行24h动态血压监测,比较各组患者日间、夜间以及全天血压的变异系数.结果冠心病多支病变组患者24h收缩压、舒张压变异性,夜间收缩压、舒张压变异性以及日间收缩压变异性均显著高于单支病变组(P<0.05);有颈动脉斑块组患者日间收缩压和舒张压变异系数以及24h收缩压变异系数均显著大于无颈动脉斑块组(P<0.05).结论老年高血压患者血压变异系数与冠心病病变程度及颈动脉斑块的形成密切相关.

Objective To discuss the relationship between blood pressure variation and carotid artery plaque in elderly patients with hypertension and coronary heart disease.Methods Retrospectively analysed the data of 98 patients with hypertension and coronary heart disease,divided them into no plaque group(n=33)and plaque group(n=65)according to carotid ultrasound examination,divided them into single-vessel lesion group(n=56)and multivessel lesion group(n=42)according to coronary arteriography.All patients underwent 24h dynamic blood pressure monitoring.The blood pressure variation in daytime,nighttime and whole day were compared.Results Variability of systolic and diastolic blood pressure in nighttime,24h and systolic blood pressure in daytime of multi-vessel lesion group were higher than single-vessel lesion group(P<0.05),variability of systolic and diastolic blood pressure in daytime,variability of 24h systolic pressure in plaque group were higher than no plaque group(P<0.05).Conclusion The variability of blood pressure is closely related to the degree of coronary heart disease and formation of carotid plaque in elderly patients with hypertension.