972例体检者及14C-呼气试验阳性者胃蛋白酶原的分析

Analysis of the results of pepsinogen test in 972 physical examination populations and in 14C-positive breath test

目的:了解胃癌高发地区人群血清胃蛋白酶原(PG)的分布特点及胃黏膜萎缩阳性率与性别年龄的关系.方法:分析医院972例体检者PG检测结果.按性别及不同年龄段分组,比较PG含量各组的分布水平及胃黏膜萎缩阳性率.比较中年组(36~54岁)中25例14C-呼气试验(14C-UBT)阳性者与25例阴性者的血清PG水平.结果:体检人群中PG呈正态分布,男性女性PG无显著差异;PGⅠ中年组和老年组明显低于青年组(男F=17.753,P<0.05;女F=12.31,P<0.05).PGⅠ/Ⅱ随着年龄的增加而下降(男F=25.32,P<0.05;女F=13.69,P<0.05).胃黏膜萎缩阳性率:强阳性:1.54%,阳性:5.76%,疑似阳性:6.89%,阴性:87.35%,男性随着年龄增加阳性率逐步增加(男性χ2=26.10,P<0.05).14C-UBT阳性组的PGⅠ、PGⅠ/Ⅱ值较阴性组水平降低(P<0.05),PGⅡ水平升高(P<0.05).结论:不同性别PG水平无显著差异,年龄影响PG水平.幽门螺旋杆菌(Hp)感染与PG改变关系密切.

Objective: To investigate the distribution characteristics of serum Pepsinogen (PG) in population with high incidence of gastric cancer and the relationship between the positive rate of gastric mucosa atrophy and the age of sex. Methods: The results of PG test of 972 local medical examiners were analyzed. By sex and age groups, the distribution levels and gastric mucosal atrophy positive rates of PG were compared. Comparison of serum PG levels of 25 patients with 14C-UBT positive and 25 negative in middle age group(36~54 years old). Results: The levels of Pepsinogen in the group were Normal distribution, there was no significant difference in the level of Pepsinogen in male and female patients. The PGI level middle-aged group and the elderly group were significantly lower than the youth group(male F=17.753, P< 0.05;Female F=12.31, P< 0.05). PGⅠ/Ⅱ decreases with age (male F=25.32, P <0.05;Female F= 13.69, P<0.05). The positive rate of gastric mucosa atrophy showed that: strong positive: 1.54 %, positive: 5.76 %, suspected positive: 6.89 %, negative: 87.35 %. The male positive rate increases gradually with age (male χ2= 26.10, P< 0.05). The PGI and PGⅠ/Ⅱ values of the 14C-UBT positive group were lower than those of the negative group (P< 0.05), PGII level increase (P< 0.05).Conclusion: There was no significant difference in the level of PG by sex .Age affected the level of PG. Helicobacter pylori(Hp) infection is closely related to PG changes.