临床无肌病性皮肌炎与皮肌炎临床差异的探究

The Clinical Differences Between Amyopathic Dermatomyositis and Typical Dermatomyositis

目的通过对本研究中临床无肌病性皮肌炎(CADM)及皮肌炎(DM)的回顾性对比分析,加深对CADM与DM各方面差别的了解。方法回顾性研究郑州大学第一附属医院2014年1月1日-2016年1月1日期间入院治疗的111例皮肌炎患者,对30例CADM及81例DM患者进行对比分析。结果CADM组合并肺间质病变和关节炎的比例显著高于DM组,在发病年龄、始发症状、血脂水平等方面两组间差异有统计学意义(P<0.05);而在抗核抗体谱、ESR、CRP水平方面两组间差异无统计学意义;两组在糖皮质激素用量方面差异无统计学意义。结论CADM较DM有更高的肺间质病变、关节炎及恶性肿瘤的发生率,DM有更高的血脂异常的发生率。

Objective To deepen the understanding of the differences between amyopathic dermatomyositis(CADM)and typical dermatomyositis(DM)through retrospective comparative analysis.Methods A retrospective study was performed on 111 patients with dermatomyositis admitted to the First Affiliated Hospital of Zhengzhou University from January 1st,2014,to January 1st,2016.We compared 30 patients with CADM and 81 patients with DM.Results The proportion of CADM combined with interstitial lung disease(ILD)and arthritis was significantly higher than that of the DM group.There were significant differences in age of onset,initial symptoms,and lipid levels between the two groups(P<0.05).There were no significant differences in ANA,ESR and CRP levels,and amount of glucocorticoid between the two groups.Conclusion CADM has a higher incidence of ILD and arthritis than DM,and DM has a higher prevalence of dyslipidemia.