三种氧化型胆固醇的炎症免疫学研究进展

Advances of three oxysterols in inflammation and immunology

目的了解三种重要的氧化型胆固醇(25-、27-羟基胆固醇及7a,25-羟基胆固醇)在炎症及免疫性疾病中的研究进展,为相关的基础研究及疾病治疗提供依据。方法复习近年来关于这3种重要的氧化型胆固醇在炎症及免疫性疾病中研究进展的相关文献并加以综述。结果25-及27-羟基胆固醇可通过多种机制干预多种病毒侵袭宿主的过程从而发挥抗病毒效应,不仅如此,二者还在多种炎性过程及炎性疾病中发挥着重要的调节作用。7a,25-羟基胆固醇主要通过作用于炎性及免疫细胞膜受体G蛋白偶联受体183亦即EB病毒诱导受体2而发挥趋化作用,从而在多种炎性免疫过程中发挥重要的调节作用。结论25-、27-羟基胆固醇及7a,25-羟基胆固醇通过作用于多种核受体及膜受体在多种炎性免疫反应及炎性免疫性疾病的发生及发展过程中发挥着重要的作用。

Objective To summarize progress of 25-hydroxycholesterol (25-OHC), 27-hydroxycholesterol (27-OHC), and 7a,25-hydroxycholesterol (7a,25-OHC) three oxidized cholesterols in inflammation and immunology and to provide evidence for related basic researches and diseases treatments. Method The relevant literatures about these three important oxidized cholesterols in the inflammation and immunology in recent years were reviewed. Results The 25-OHC and 27-OHC could exert the antiviral effects by interfering with various viruses invading the host via various mechanisms. Moreover, the 25-OHC and 27-OHC also played the important regulatory roles in a variety of inflammatory processes and inflammatory diseases. The 7a,25-OHC played the important role in a variety of inflammatory processes by acting on the inflammatory and immune cell membrane receptor G-protein coupled receptor 183 (also known as Epstein- Barr virus-inducible receptor 2). Conclusion 25-OHC, 27-OHC and 7a,25-OHC play an important roles in occurrence and development of various inflammatory and immune responses and diseases of inflammatory and immune by acting on a variety of nuclear receptors and membrane receptors.