长链非编码RNA调控自噬以影响肿瘤耐药的研究进展

Recent advances of long non-coding RNA in tumor resistance by regulating autophagy

目的总结长链非编码RNA(LncRNA)调控自噬以影响肿瘤耐药的研究进展。方法查阅国内外相关文献,就LncRNA调控自噬以影响肿瘤耐药的最新研究进展进行综述。结果耐药是抗肿瘤治疗过程中普遍存在的问题,自噬作为重要的维持细胞稳态的机制,在肿瘤耐药过程中发挥了重要的作用。LncRNA的调控异常可促成肿瘤的发生和发展,也可以通过促进或者抑制自噬而介导肿瘤细胞对抗肿瘤药物产生耐药。结论LncRNA可以正向或者负向介导肿瘤自噬,而自噬对于肿瘤耐药是一把“双刃剑”。LncRNA可能通过调控自噬来改善肿瘤对药物的耐药性。

Objective To summarize the recent advances in the relationship between long non-coding RNA (LncRNA) and tumor autophagy, autophagy and drug resistance regulation. Methods Reviewed the relevant literatures at home and abroad, and reviewed the recent research progress of LncRNA regulation of autophagy to affect tumor resistance. Results Drug resistance was a common problem in the process of anti-tumor therapy. Autophagy played an important role in the process of tumor resistance as an important mechanism to maintain cell homeostasis. Abnormal regulation of LncRNA could contribute to the occurrence and development of tumors, and could also mediate the resistance of tumor cells to anti-tumor drugs by promoting or inhibiting autophagy. Conclusions LncRNA can mediate tumor autophagy in a positive or negative direction, and autophagy is a "double-edged sword" for tumor resistance. LncRNA may improve tumor resistance to drugs by regulating autophagy.