重组人粒细胞集落刺激因子联合抗生素治疗急性白血病化疗后中性粒细胞缺乏合并感染患者的临床效果

Clinical effect of recombinant human granulocyte colony-stimulating factor combined with antibiotics in the treatment of acute leukemia patients with neutropenia complicated with infection after chemotherapy

目的探究重组人粒细胞集落刺激因子联合抗生素治疗急性白血病(AL)化疗后中性粒细胞缺乏合并感染患者的临床效果。方法选取于我院接受治疗的AL化疗后中性粒细胞缺乏合并感染的80例患者作为观察对象,通过随机数表法将其分为对照组与研究组,各40例。对照组单纯予以抗生素治疗,研究组则在对照组的治疗基础上予以重组人粒细胞集落刺激因子治疗。比较两组的治疗效果。结果研究组的中性粒细胞恢复正常时间、体温恢复正常时间及抗生素使用时间均显著短于对照组(P<0.05)。治疗后,两组患者中性粒细胞、PCT、CRP、IL-6水平均优于治疗前,且研究组优于对照组(P<0.05)。治疗后,两组KPS评分均显著升高,且研究组高于对照组(P<0.05)。结论重组人粒细胞集落刺激因子联合抗生素治疗可以显著改善AL患者化疗后的中性粒细胞水平低下及感染情况,可促进患者恢复,加强患者自身的体质及功能状态,进而提高化疗的耐受性,因此该治疗方法具备临床推广价值。

Objective To explore the clinical effect of recombinant human granulocyte colony-stimulating factor combined with antibiotics in the treatment of acute leukemia (AL) patients with neutropenia complicated with infection after chemotherapy. Methods Eighty patients with neutropenia complicated with infection after chemotherapy for AL in our hospital were selected as the observation objects and divided into control group and study group by random number table method, with 40 cases in each group. The control group was treated with antibiotics only, while the study group was treated with recombinant human granulocyte colony-stimulating factor combined with antibiotics. The therapeutic effects of the two groups were compared. Results The neutrophil recovery time, body temperature recovery time and antibiotic use time in the study group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of neutrophils, PCT, CRP and IL-6 in the two groups were better than those before treatment, and those in the study group were better than the control group (P<0.05). After treatment, the KPS scores of the two groups increased significantly, and that of the study group was higher than the control group (P<0.05). Conclusion Recombinant human granulocyte colony-stimulating factor combined with antibiotics can significantly improve the symptoms of low neutrophil level and infection in patients with AL after chemotherapy. It can promote the recovery of patients, strengthen their own physical and functional status, and then improve the tolerance of chemotherapy. Therefore, the treatment method has clinical popularization value.