布地奈德联合沙丁胺醇对支气管哮喘患者肺功能及血清炎症因子的影响

Effects of budesonide combined with salbutamol on pulmonary function and serum inflammatory factors in patients with bronchial asthma

目的分析布地奈德联合沙丁胺醇对支气管哮喘患者肺功能及血清炎症因子的影响。方法将122例支气管哮喘患者根据随机双盲法分为对照组与联合组,各61例。对照组给予沙丁胺醇治疗,联合组给予布地奈德+沙丁胺醇治疗。比较两组的治疗效果。结果联合组治疗总有效率高于对照组(P<0.05)。治疗2周后,两组FVC、FEV1、MMF均升高,EOS、IL-17及IL-33水平均降低,且联合组优于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论布地奈德联合沙丁胺醇治疗支气管哮喘患者效果确切,有利于改善肺功能,调节气道炎症,且未增加不良反应。

Objective To analyze the effects of budesonide combined with salbutamol on pulmonary function and serum inflammatory factors in patients with bronchial asthma. Methods A total of 122 patients with bronchial asthma were divided into control group and combined group according to random double-blind method, with 61 cases in each group. The control group was treated with salbutamol, while the combined group was treated with budesonide+salbutamol. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the combined group was higher than that in the control group (P<0.05). After 2 weeks of treatment, the FVC, FEV1 and MMF increased, the levels of EOS, IL-17 and IL-33 decreased in both groups, and those in the combined group were better than the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Budesonide combined with salbutamol in the treatment of patients with bronchial asthma has a definite effect, which is conducive to improving pulmonary function and regulating airway inflammation, without increasing adverse reactions.