Yes相关蛋白参与肝脏疾病作用机制的研究进展

Research progress on the Yes-associated proteins parameters and its mechanism of action in liver diseases

转录共激活因子Yes相关蛋白(YAP)参与调节多种细胞生理活动,在控制组织器官大小和维持机体内环境稳态方面发挥着重要作用。YAP不仅影响其下游靶基因的转录表达,还能与多个信号通路相互作用,形成复杂的调节网络以执行特定的生物功能。除了Hippo信号通路介导的蛋白磷酸化修饰,YAP活性作用的调控机制还涉及到多个方面。YAP的活性变化可以对肝脏组织形态特征及生理功能产生影响,参与肝纤维化、原发性肝癌等肝脏疾病的发生和发展。现主要讨论YAP与肝脏生理病理之间的密切关系,旨在为进一步挖掘其在肝脏疾病分子靶向治疗中的潜在应用提供参考。

The transcriptional coactivator Yes-associated protein (YAP) is involved in the regulation of various cellular physiological activities and plays an important role in controlling the size of tissues and organs for maintaining the homeostasis. YAP not only affects the transcriptional expression of its downstream target genes, but also interacts with multiple signaling pathways to form complex regulatory networks to perform specific biological functions. In addition to Hippo signaling pathway mediated protein phosphorylation, the regulatory mechanisms of YAP activity also takes part in multiple fields. YAP activity alteration can affect the morphological characteristics and physiological functions of liver tissue, and participate in the occurrence and development of liver diseases, such as liver fibrosis and primary liver cancer. This paper mainly discusses the close relationship between YAP and liver pathophysiology, in order to provide reference for further exploring its potential application in molecular targeted therapy of liver diseases.