摘要
活性维生素D可用于治疗多种疾病和调节人与动物机体的重要生理活动,应用前景广泛。本文概述了已上市的9种活性维生素D类药物的药理活性及合成方法,并总结了这些合成方法的优缺点,为该系列药物的工业化生产提供一定的参考依据。
Active vitamin D can be used to treat disease and regulate physiological activities of human and animals, which have wide application prospects. This review briefly introduced the biological activity and synthetic methods of nine commercially available active vitamin D drugs. It summarized synthetic advantages or disadvantages of different methods, providing certain guidance for the industrial production of vitamin D in the future.
作者
张凉
孙彬
苏为科
金灿
ZHANG Liang;SUN Bin;SU Weike;JIN Can(College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014;Collaborative Innovation Center of Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014;National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Hangzhou 310014)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2019年第7期695-711,共17页
Chinese Journal of Pharmaceuticals
关键词
活性维生素D
合成
综述
active vitamin D
synthesis
review
