纳米制剂在类风湿性关节炎靶向治疗中的应用研究

Researches on Nanomedicines in Targeted Therapy of Rheumatoid arthritis

类风湿性关节炎(rheumatoid arthritis,RA)是一种慢性系统性炎症病变,一旦发病难以根治。临床上已有许多治疗RA 的药物,但由于给药后在病变关节的分布较少,导致疗效不理想且不良反应严重,同时这些药物普遍存在生物利用度差、给药剂量高、给药次数频繁等问题。为了提高药物在病变关节的靶向分布,将药物有效递送至炎症部位,利用被动靶向、主动靶向、微环境响应靶向以及仿生靶向策略的纳米制剂成为近年来RA 诊断与治疗的研究热点,在取得良好抗炎效果的同时提高了安全性。本文对近年来纳米制剂在RA 靶向治疗中的研究和应用进行了综述。

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. It will be a progressive disease that lasts for a lifetime once it occurs. Although many RA drugs have been used in clinical treatment, high doses and frequent administration are necessary for their short biological half-life and poor bioavailability. To solve these problems, targeted nanomedicines have become novel drug delivery systems for the diagnosis and treatment of RA. It can effectively deliver drugs to the inflammation sites by passive targeting, active targeting, microenvironment responsive targeting and biomimetic targeting strategies and ultimately improve the anti-inflammatory effect and safety. In this paper, the research and application of nanomedicines in the targeted therapy of RA are reviewed.