吸入噻托溴铵干粉与异丙托溴铵定量气雾剂治疗慢性阻塞性肺疾病的疗效与安全性比较

Comparison Efficacy and Safety of Inhaled Tiotropium Bromide Dry Powder and Isopropyl Bromide Quantitative Aerosol in the Treatment of Chronic Obstructive Pulmonary Disease

目的:分析吸入噻托溴铵干粉与异丙托溴铵定量气雾剂治疗慢性阻塞性肺疾病的疗效与安全性。方法:选取2015年5月~2017年10月某科收治的慢性阻塞性肺疾病的病患110例,按照用药方法不同将患者分为治疗1组及治疗2组,分别予以吸入噻托溴铵干粉与异丙托溴铵定量气雾剂治疗,对比治疗效果。结果:治疗1组在接受治疗后肺功能相关指标改善情况与治疗2组相比更佳;治疗1组在用药期间不良反应发生率与治疗2组相比更低,组间相比可见统计学差异,P<0.05。结论:慢性阻塞性肺疾病采用噻托溴铵干粉吸入与异丙托溴铵定量气雾剂相比疗效更佳,对患者肺功能改善更加明显,且具备一定安全性,利于患者接受。

Objective: To analyze the efficacy and safety of inhaled tiotropium bromide dry powder and isopropyl bromide quantitative aerosol in the treatment of chronic obstructive pulmonary disease(COPD). Methods: A total of 110 patients with chronic obstructive pulmonary disease(COPD) admitted by a department from May 2015 to October 2017 were selected and divided into treatment group 1 and treatment group 2 according to different methods of medication. The patients were treated with inhaled tiotropium bromide dry powder and isopropyl bromide quantitative aerosol respectively. The treatment effect were compared. Results: The improvement of pulmonary function in treatment group 1 was better than that in treatment group 2. The incidence of adverse reactions during medication in the treatment group 1 was lower than that in the treatment group 2, and there was a statistical difference between the two groups(P<0.05). Conclusion: The efficacy of inhalaed tiotropium bromide dry powder is better than that of isopropyl bromide quantitative aerosol in the treatment of chronic obstructive pulmonary disease(COPD). The improvement of pulmonary function is more obvious, and it is safe and easy for patients to accept.