血清降钙素水平的监测对指导抗菌药物治疗肺部感染患者临床应用的价值分析

Clinical Value of Serum Calcitonin Monitoring in Antibiotic Therapy of Pulmonary Infection

目的:探究血清降钙素(procalcitonin,PCT)水平的监测对指导抗菌药物治疗肺部感染患者的临床应用价值。方法:选取2017年1 1月-2018年11月间收治的肺部感染患者72例资料,按治疗方法和PCT检测结果将其随机分为对照组患者和观察组患者,每组36例;对照组患者给予抗菌药物常规治疗,观察组患者在PCT水平监测指导下给予抗菌药物治疗;比较两组患者抗菌药物使用时间和总有效率的差异,以及CRP、WBC水平的变化情况。结果:观察组患者抗菌药物治疗时间和住院时间均短于对照组(P<0.05),抗菌药物治疗费用和总费用均低于对照组(P<0.05),总有效率高于对照组(P<0.05);两组患者CRP与WBC水平值经组间比较其差异均无统计学意义(P>0.05)。结论:针对肺部感染患者,监测PCT水平以指导临床抗菌药物的使用,可缩短抗菌药物治疗时间,促进了患者的康复。

Objective: To explore the clinical application value of serum procalcitonin(PCT) level monitoring in guiding the antibiotics treatment in patients with pulmonary infection. Methods: Data of 72 patients with pulmonary infection admitted from January 2017 to November 2018 were selected. According to the treatment method and PCT test results, the patients were randomly divided into control group and observation group, with 36 patients in each group. Patients in the control group were given routine treatment with antimicrobial agents, and patients in the observation group were given antimicrobial agents under the guidance of PCT level monitoring. To compare the difference between the two groups in the duration of antimicrobial use and the total effective rate, as well as the changes in CRP and WBC levels. Results: The treatment time and hospitalization time of the observation group were shorter than those of the control group(P<0.05). The cost of antibacterial treatment and the total cost were lower than those of the control group(P<0.05). The total effective rate was higher than that of the control group(P<0.05). There was no significant difference in CRP and WBC levels between the two groups(P>0.05). Conclusion: For patients with pulmonary infection, monitoring the PCT level to guide the use of clinical antibiotics can shorten the treatment time of antibiotics and promote the recovery of patients.