分泌型C1q在突触的形成和调控中的作用研究进展

Role of secretory C1q protein in the formation and regulation of synapse

C1q家族是C1复合物的组分之一,能够识别免疫复合物,启动补体系统经典途径,此外,作为一种模式识别受体(pattern recognition receptor,PRR)分子,它可以结合种类繁多的配体。分泌型C1q作为C1q家族成员之一,包括多种亚型,主要的亚型有小脑肽(cerebellin,Cbln)及C1q类似蛋白(C1q-like protein,C1ql)。在神经系统中,分泌型C1q参与多种类型突触的形成和调控,因而分泌型C1q与中枢神经系统疾病关系密切。本文就分泌型C1q在突触形成和调控中的作用以及与疾病相关性进行综述。

The C1q family is one of the subcomponents of the C1 complex that recognizes immune complexes and initiates the classical pathway of the complement system. In addition, as a pattern recognition receptor(PRR), the C1q family binds to a wide variety of ligands. As a member of the C1q family, the secretory C1q includes several subtypes. The main subtypes are cerebellin(Cbln) and C1q-like protein(C1ql). In the nervous system, secretory C1q is involved in the formation and regulation of various types of synapses,thus secretory C1q is closely related to diseases of the central nervous system. In this article, we review the role of secretory C1q in synapse formation and regulation, and its relationship with some diseases of the central nervous system.