追赶生长与高尿酸血症的相关性研究

The correlation between catch-up growth and hyperuricemia

目的:研究追赶生长人群代谢状况变化,探讨追赶生长是否与高尿酸血症(hyperuricemia,HUA)相关以及是否为HUA的危险因素。方法:2014年于宜昌市夷陵区进行人群调查研究,共有6 685名居民参与。对所有研究对象进行体格检查和问卷调查,同时采集空腹及糖负荷后2 h静脉血,进行血糖、血脂、尿酸等指标检测。在剔除584名资料不全者后,对余下6 101名的数据进行分析。根据是否存在低营养后营养水平提升将受试者判定为追赶生长或非追赶生长,比较2组的代谢状况,Logistic回归分析追赶生长人群发生HUA的优势比(odds ratio,OR)。结果:与非追赶生长人群相比,追赶生长人群具有更高的体质量指数(body mass index,BMI)、收缩压、三酰甘油(triglyceride,TG)水平,更低的高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)水平;进一步亚组分析显示,在女性,追赶生长HUA患病比例和血尿酸水平明显高于非追赶生长(P<0.001),而在男性,追赶生长与非追赶生长HUA患病比例和血尿酸水平差异无统计学意义(P>0.1);经Logistic多元回归分析校正年龄、BMI、吸烟、饮酒、血压、空腹血糖、糖负荷后2 h血糖、TG等因素后,结果显示追赶生长女性发生HUA的风险较非追赶生长显著升高,OR值为1.415(P=0.022),95%可信区间(confidence interval,CI):1.272~2.795。结论:追赶生长人群较多出现代谢异常,且追赶生长与HUA相关,是HUA的独立危险因素。

Objective To characterize the metabolic profile of individuals with catch-up growth and explore the association between hyperuricemia(HUA)and catch-up growth.Methods A population-base investigation including physical examination and questionnaire survey was conducted in Yiling District of Yichang City 2014 and enrolled a total of 6 685 participants.The peripheral blood samples were collected after overnight fasting and 2 hours post glucose tolerance test for chemical analysis.The investigated subjects were divided into two groups,catch-up growth group and non-catch-up growth group,who had nutrition promotion after undernutrition.Data analysis were accomplished with 6 101 cases after elimination of 584 cases with missing data.Independent samples t-test,Chi-square test and Logistic regression analysis were employed.Results Higher body mass index(BMI),systolic blood pressure,triglyceride(TG)level and lower high-density lipoprotein cholesterol(HDL-C)level were observed in catch-up growth.The analysis of subgroups showed that the prevalence of HUA and blood uric acid level were significantly higher in catch-up growth in female(P<0.001),while there was no significant difference in male(P>0.1).After adjustment for age,BMI,smoking,drinking,blood pressure,fasting blood sugar,2-h post-load plasma glucose and TG,Logistic multiple regression analysis showed that the risk of HUA was significantly higher in catch-up growth female[odds ratio(OR):1.415,P=0.022,95%confidence interval(CI):1.272-2.795].Conclusions Catch-up growth individuals are more predisposed to the metabolic disorders.A significant correlation was observed between catch-up growth and HUA,indicating catch-up growth is an independent risk factor for HUA.