胰岛素泵治疗对高龄妊娠期糖尿病患者的影响

Effect of Insulin Continuing Pumping on Blood Glucose and Mother-Fetus Outcome in Senile Patients with Gestational Diabetes Mellitus

目的:研究胰岛素持续泵入治疗对高龄妊娠期糖尿病患者血糖及母婴结局的影响。方法:根据随机双盲法将2017年2月至2018年8月在深圳市第二人民医院就诊的86例高龄妊娠期糖尿病患者分为两组,各43例。比较两组血糖控制情况、同型半胱氨酸(Hcy)、胱抑素C(CysC)水平以及母婴结局。结果:治疗后,两组空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)水平均较治疗前低,且观察组低于对照组,差异具有统计学意义(P<0.05);治疗后,两组Hcy、CysC水平均较治疗前低,且观察组低于对照组,差异均具有统计学意义(P<0.05);观察组产妇并发症发生率、新生儿并发症发生率均较对照组低,组间比较,差异具有统计学意义(P<0.05)。结论:胰岛素持续泵入治疗可帮助高龄妊娠期糖尿病患者控制血糖,改善Hcy、CysC水平,同时可大幅降低母婴并发症风险。

Objective To investigate the effect of insulin continuing pumping on blood glucose and mother-fetus outcome in senile patients with gestational diabetes mellitus(GDM). Methods 86 senile GDM patients in the hospital from February 2017 to August 2018 were divided into two groups by randomized double blind method, 43 cases each. The blood glucose control, Hcy, Cys C,mother-fetus outcome were compared between the two groups. Results After treatment, the levels of FPG, 2 h PG, HbA1 c in the two groups were lower than those before treatment, and research group was lower than control group(P < 0.05);After treatment, the levels of Hcy and Cys C in the two groups were lower than those before treatment, and research group was lower than control group(P < 0.05);The incidence of maternal and neonatal complications in research group was lower than that in control group(P < 0.05).Conclusion Insulin continuing pumping in treatment of senile patients with GDM can control blood glucose, improve the levels of Hcy and Cys C, decrease the risks of mother-fetus complications.