LMO1基因rs4758051多态性与神经母细胞瘤易感性关系的Meta分析

Meta analysis on relationship between LMO1 rs4758051 polymorphism and neuroblastoma susceptibility

目的探讨LMO1基因多态性与神经母细胞瘤(NB)易感性的关系。方法通过计算机检索PubMed、Embase、WebofScience、Cochranelibrary、中国生物医学数据库、中国知网和万方数据库,收集LMO1基因多态性与神经母细胞瘤易感性的相关研究,检索时限均从数据库建立至2018年11月。根据制定的相关标准对已公开发表的中、英文文献进行筛选,研究类型为病例-对照研究,对照组与病例组来自同一人群而且符合哈德-温伯格平衡。采用Stata12软件处理数据并进行Meta分析。结果最终纳入关于LMO1基因多态性与NB易感性关联的病例-对照研究7篇文献,共计病例组2709例,对照组3717例。基因型Gvs.A多态性与神经母细胞瘤存在相关性[OR=1.20,95%CI(1.05~1.37),P=0.009]。基因型GGvs.AA+AG多态性与神经母细胞瘤存在相关性[OR=1.27,95%CI(1.01~1.60),P=0.041]。按种族进行亚组分析,亚洲人中各研究间异质性降低至可接纳范围内,Meta分析结果与总体人群类似。结论LMO1rs4758051位点单核苷酸多态性与神经母细胞瘤的发病风险存在相关性,G等位基因和GG、GA基因型会增加患神经母细胞瘤的风险。

Objective To analyze the relation between LIM domin only 1(LMO1) gene polymorphism and neuroblastoma(NB) susceptibility. Methods Six electronic databases , including PubMed, EMBASE, Web of Science, Cochrane, Chinese Biomedical Literature(CBM), China National Knowledge Infrastructure (CNKI)and Wanfang databases were searched to select eligible publications on the relationships of LMO1 gene polymorphisms with NB susceptibility publicate from the establishment November 2018. According to the inclusion and exclusion criteria, relevent studies were selected. All of these studies were case-control studies in which the control group and the case group came from the same population and were consistent with the Harder-Weinberg equilibrium. The data was processed by Stata 12 software and analyzed by Meta. Results The study included seven case-control studies, the total number of patients in case groups was 2 709, it was 3 717 in control groups. Genotype G vs. A polymorphism was associated with NB(OR=1.20, 95% CI : 1.05-1.37, and P=0.009). Genotype GG vs. AA+ AG polymorphism was associated with NB (OR = 1.27 , 95% CI : 1.01-1.60, P=0.041). After subgroup analysis by race, the heterogeneity of studies among Asians was reduced to an acceptable range, and the results of Meta analysis were similar to those of the general population. Conclusions LOM1rs4758051 polymorphism is significantly associated with the susceptibility of NB. G allele and GG and GA genotypes can increase the risk of NB.