儿童肝母细胞瘤56例临床特点及预后分析

Clinical characteristics and prognosis of 56 cases hepatoblastoma in children

目的分析儿童肝母细胞瘤的临床特点、疗效及预后。方法总结2010年1月至2016年6月郑州儿童医院血液肿瘤科收治的肝母细胞瘤患儿56例,根据国际儿童肿瘤协会的PRETEXT分期进行肿瘤分期,采用手术联合化疗的治疗方法,评估56例患儿的疗效及预后。结果56例患儿中男34例,女22例,发病年龄为3~70个月,平均19个月。随访至2017年6月30日,平均随访时间为8~72个月,3年总生存率为68.5%,3年无事件生存率为55.3%,病死率为23.2%。结论儿童肝母细胞瘤发病年龄小,经手术联合术前及术后化疗治疗可有效延长生存率,提高临床治愈率。

Objective To analyze the clinical characteristics , curative effect and prognostic factor of childhood hepatoblastoma. Methods The clinical clata of 56 children with hepatoblastoma admitted to the Hematopoietic Oncology Department of Zhengzhou Children’s Hospital from January 2010 to June 2016 were summarized. Tumor staging was based on PRTEXT staging of the International Association of Childhood Oncology.Surgery and chemothereapy were applied .The clinical characteristics, curative effect and prognostic factor of hepatoblastoma in children were analyzed. Results There were 34 boys and 22 girls in the 56 patients, the age of onset was 3 – 70 months, with an average age of 19 months. Patients were followed up until 30 June 2017, with mean follow-up time of 8 to 72 months. The 3-year overall survival rate (OS) was 68.5%, the 3-year event-free survival rate (EFS) was 55.3%, and the fatality rate was 23.2%. Conclusions Hepatoblsatoma develops in very young age of children, surgical resection combined with preoperative and postoperative chemotherapy can effectively prolong the survival rate, and improve the clinical cure rate.