眼针联合氯吡格雷与阿托伐他汀治疗脑梗死的疗效及安全性

Efficacy and safety of eye acupuncture combined with clopidogrel and atorvastatin in the treatment of cerebral infarction

目的评估眼针联合氯吡格雷与阿托伐他汀治疗脑梗死的疗效及其对血液流变学、神经功能缺损程度的影响。方法选取2017年1月至2018年4月山西省眼科医院收治的脑梗死患者90例,随机分为对照组(给予氯吡格雷联合阿托伐他汀治疗)和观察组(给予眼针联合氯吡格雷与阿托伐他汀治疗),每组45例。记录两组患者治疗前后神经功能缺损程度评分、血流动力学指标以及治疗总有效率并进行比较。结果治疗后两组患者纤维蛋白原、D-二聚体均明显降低,且治疗后观察组纤维蛋白原、D-二聚体水平均降低更为显著(P均<0.05)。治疗后两组患者BI评分明显升高,mRS评分以及NIHSS评分均明显降低,且治疗后观察组各指标均改善更为显著(P均<0.05)。在治疗过程中两组患者均无明显不良反应,观察组治疗总有效率[95.56%(43/45]高于对照组[75.56%(34/45),P<0.05)]。结论眼针联合氯吡格雷与阿托伐他汀治疗脑梗死疗效显著,对患者血液流变学紊乱以及神经功能具有明显的改善作用。

Objective To evaluate the efficacy of ocular acupuncture combined with clopidogrel and atorvastatin in the treatment of cerebral infarction and its effect on hemorheology and neurological deficits. Methods Ninety patients with cerebral infarction admitted to Shanxi Ophthalmological Hospital from January 2017 to April 2018 were randomly divided into control group (treated with clopidogrel combined with atorvastatin) and observation group (treated with eye acupuncture combined with clopidogrel and atorvastatin), with 45 cases in each group. The neurological deficit scores, hemodynamic parameters and the total effective rate of the two groups were recorded and compared before and after treatment. Results The fibrinogen and D-Dimer of the two groups after treatment were significantly decreased, and the levels of fibrinogen and D-Dimer of the observation group were significantly lower than those in the control group(P all<0.05). After treatment, the BI scores of the two groups were significantly increased, the mRS scores and NIHSS scores were significantly decreased, and the indicators of observation group were improved more significantly(P all<0.05). The total effective rate of observation group was 95.56%(43/45), significantly higher the 75.56%(34/45)control group (P<0.05). Conclusions The curative effect of eye acupuncture combined with clopidogrel and atorvastatin on cerebral infarction is significant, which has significance in the improvement of hemorheology and neurological function.