肌钙蛋白I、肌红蛋白和肌酸激酶同工酶检测在急性心肌梗死诊断中的价值

Diagnostic significance of troponin I, myoglobin and creatine kinase isoenzyme for acute myocardial infarction

目的探讨肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、肌红蛋白(Myo)用于诊断急性心肌梗死(AMI)的临床价值。方法选取山西省心血管病医院2016年8月至2018年2月收治的120例急性心肌梗死患者为研究组,同期来医院就诊的120例非急性心肌梗死心血管疾病患者为对照1组,同期来医院体检的120例健康人群为对照2组。检测三组cTnI、Myo、CK-MB水平,并将所得数据输入统计学软件进行分析。结果研究组cTnI、Myo、CK-MB水平最高,而对照2组上述指标水平最低,三组间两两比较差异均有统计学意义(P均<0.05);研究组cTnI、Myo、CK-MB检测阳性率均高于对照1组、对照2组(P均<0.05)。结论应用cTnI、Myo、CK-MB联合诊断急性心肌梗死有利于提高疾病检出率,使患者尽快接受对症救治,对保障其疗效及预后具有积极意义。

Objective To investigate the clinical value of troponin I (cTnI), creatine kinase isoenzyme (CK-MB) and myoglobin (Myo) in the diagnosis of acute myocardial infarction (AMI). Methods One hundred and twenty AMI patients hospitalized in Shanxi Provincial Cardiovascular Hospital from August 2016 to February 2018 were selected as study group;120 patients who visited hospital for cardiovascular diseases exlepting AMI during the same period were allocated into control group 1, and 120 healthy persons who underwent physical examination during the same period were selected as control group 2. The levels of cTnI, Myo and CK-MB were determined in the three groups. The results of the above indicators were recorded and the data were put into the statistics for analysis. Results The levels of cTnI, Myo and CK-MB in study group were the highest, while those in control group 2 were the lowest among the three groups (P all <0.05). The positive rates of cTnI, Myo and CK-MB in study group were significantly higher than those in control group 1 and control group 2 (all P<0.05). Conclusions The combination of cTnI, Myo and CK-MB in the diagnosis of AMI has important clinical value, which is conducive to improving the detection rate of patients and allowing patients to receive symptomatic treatment as soon as possible, which is of positive significance for ensuring treatment efficacy and prognosis.