围绝经期冠心病患者血清总胆汁酸、胆固醇水平的变化及相关性

Changes of serum total bile acid and cholesterol in perimenopausal patients with coronary heart disease and their relationship

目的探讨血清总胆汁酸水平、胆固醇水平在围绝经期冠心病患者中的变化及总胆汁酸水平与胆固醇水平的相关性。方法随机选取郑州大学第一附属医院2017年7月至2018年9月240例年龄39~57岁拟诊为冠心病收入院且行冠脉动脉造影的围绝经期患者。根据冠状动脉造影检查结果,将入选患者分为冠心病组(n=135)和非冠心病组(对照组,n=105)。比较两组一般资料及血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和血清总胆汁酸的差异,并分析总胆汁酸与冠心病的关系及与胆固醇的相关性。结果冠心病组总胆固醇、低密度脂蛋白胆固醇和总胆汁酸水平均高于对照组(P均<0.05)。Logistic回归分析示糖尿病、总胆固醇和总胆汁酸是围绝经期冠心病患者的独立危险因素,OR值分别为4.061、1.984、1.125,相关性分析示总胆汁酸水平与总胆固醇水平存在正相关(r=0.799,P<0.05)。结论总胆汁酸水平与围绝经期患者冠心病的发生和总胆固醇代谢密切相关。

Objective To investigate the changes of serum total bile acid levels and cholesterol levels in perimenopausal patients with coronary heart disease and their relationship. Methods A total of 240 perimenopausal patients who underwent coronary angiography in the First Affiliated Hospital of Zhengzhou University from July 2017 to September 2018 were randomly selected. Those patients were divided into coronary heart disease group (n=135) and non-coronary heart disease group (control group, n=105) according to the results of coronary angiography. The total serum cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total serum bile acids levels of the two groups were observed and the differences between those data was studied. The relationship between total bile acids and coronary heart disease and its correlation with cholesterol was analyzed. Results The levels of total cholesterol, low-density lipoprotein cholesterol and total bile acid in the coronary heart disease group were significantly higher than those in the control group (P all <0.05). Logistic regression analysis showed that diabetes, total cholesterol, and total bile acid were independent risk factors for perimenopausal patients with coronary heart disease, the OR values were 4.061, 1.984 and 1.125 respectively, and the correlation analysis showed significant positive correlation of total bile acid levels with total cholesterol levels (r=0.799, P<0.05). Conclusions Total bile acid level is closely related to the occurrence of coronary heart disease and total cholesterol metabolism in perimenopausal patients.