我国男男性行为人群HPV感染率及其与HIV感染的关系

HPV infection rate among men who have sex with men in China and its relation with HIV infection

目的描述性分析我国男男性行为(MSM)人群人乳头瘤病毒(HPV)感染率及其与人类免疫缺陷病毒(HIV)感染的关系。方法检索中国期刊全文数据库(CNKI)、重庆维普(VIP)、万方科技期刊全文数据库、Pubmed、Embase、Ovid中我国男性MSM人群HPV感染情况的流行病学研究,且有HIV感染检测结果的文献。采用Excel软件对文献数据进行列表、作图和分析。结果最终检出质量均为B级的文献11篇,发表于2010年至2017年。在MSM人群,HIV感染率和HPV感染率的曲线变化相似,HIV阳性者HPV总感染率高于HIV阴性者(前者是后者的1. 32~2. 11倍),HIV感染时HPV高危亚型(HR-HPV)感染率高于低危亚型(LR-HPV)感染率。在任何HIV感染状态下,深圳MSM人群HPV感染率(HR-HPV、LR-HPV)均低于其他城市。我国MSM群体最常见的HR-HPV为HPV16、HPV18,最常见的LR-HPV为HPV6、HPV11。结论男男性行为可能是导致我国MSM人群HPV感染率高于普通男性的重要原因,而HIV阳性是影响HPV感染的重要危险因素,尤其对HR-HPV感染影响更大。此外,西方国家相对少见的部分HR-HPV亚型在我国MSM群体的感染情况应该引起更多的关注。

Objective To descriptively analyze the infection rate of human papillomavirus( HPV) and its relation with human immunodeficiency virus( HIV) infection in men who have sex with men( MSM) in China. Methods The database of Chinese National Knowledge Infrastruction( CNKI),Chongqing Weipu( VIP),Wanfang,Pubmed,Embase and OVID database were retrieved with computer for collecting studies about the epidemiology of HPV with and/or without HIV infection in MSM in China.All extracted data were tabled and comprehensively evaluated with Excel software. Results Eleven papers with B-grade quality were published in 2010-2017. In MSM population,the HIV infection rate and HPV infection rate curve changed similar,HIV-positive people have higher HPV infection rate than HIV-negative people( the former is 1.32 ~ 2.11 times as the latter). HIV infection high risk subtype( HR-HPV) infection rate is higher than low-risk subtype( LR-HPV) infection rate. Under any HIV infection condition,the HPV infection rate( HR-HPV,LR-HPV) in MSM population in Shenzhen was lower than that in other cities. The most common HR-HPV in MSM population in China was HPV16 and HPV18,and the most common LR-HPV was HPV6 and HPV11. Conclusions The behavior of men having sex with men is possibly one of the major reasons for significantly increased HPV prevalence in MSM population than regular male population in China. HIV infection is also one of the major risk factors for HPV infection,especially for HR-HPV. Besides,some relatively rare HR-HPV subtypes in western countries should get more attention in MSM population in China.