尘肺病的发病机制与药物治疗研究进展

Progress in the pathogenesis and drug treatment of pneumoconiosis

尘肺病是长期吸入带电荷的粉尘粒子从而导致肺部一系列损伤的疾病,这一系列损伤包括直接的肺部损伤,形成活性化学物质产生细胞因子和化学因子,诱导肺部纤维化以及诱导细胞凋亡等。临床上根据不同的分期及致病机制先后开发出了一系列相关药物及治疗方案。本文综述了近年来药物治疗尘肺病的最新进展,以期为临床治疗尘肺以及药物研发提供相关参考资料。

Pneumoconiosis is a disease induced by long-term inhalation of charged dust particles and caused a series of damage to the lungs.This series of injuries included direct lung injury,formation of reactive chemicals,cytokines,and pulmonary fibrosis,and induction of apoptosis.Many drugs and treatment programs have been developed based on different stages and pathogenic mechanisms.This article reviewed the recent advances in the pharmacological treatment of pneumoconiosis to provide references for the clinical treatment of pneumoconiosis and drug development.