1例老年患者口服伏立康唑剂量调整的病例分析

Dose adjustment of oral voriconazole in an elderly patient

伏立康唑是新一代三唑类抗真菌药物,具有抗菌谱广、抗菌作用强等特点,临床上常作为治疗侵袭性曲霉菌感染的首选药物。伏立康唑在体内的代谢呈非线性药代动力学特征,血药浓度易受基因多态性、药物相互作用和病生理状态等多种因素影响,个体间呈现明显差异。本文对1例肺部真菌感染患者应用伏立康唑血药浓度偏高的原因进行分析,为临床用药提供参考。

Voriconazole is potent,second-generation triaole with broad-spectrum antifungal activity,which is used as the first choice medicine for the treatment of invasive aspergillus infection.The metabolism of voriconazole showed nonlinear pharmacokinetic profile in adults.Several factors contribute to the wide intervariability of voriconazole plasma concentrations,such as genetic polymorphism of CYP2C19,drug-drug interactions,Pathological and physiological status and so on.We present the case of a 86-year-old patient who use voriconazole and had a higher trough concentration.The reason was analysed which can be the reference for clinical.