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氧化指标与首发缺血性脑卒中的相关性研究

Study on the Correlation Between Oxidative Index and the New-onset of Ischemic Stroke
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摘要 目的研究血清谷胱甘肽还原酶、小而密低密度脂蛋白和维生素D这3个氧化指标与首发缺血性脑卒中患者的关系,探讨氧化指标在首发缺血性脑卒中的临床意义。方法收集首次发作缺血性脑卒中患者80例作为实验组,同期笔者医院健康体检者80例作为对照组,分析缺血性脑卒中患者血清中谷胱甘肽还原酶(GR)、小而密低密度脂蛋白(sd-LDL)和维生素D(VD)等指标的表达;并评价各指标对患者严重程度的临床价值。结果患者组GR水平较健康对照组低,差异有统计学意义(P<0.05),sd-LDL、GR和VD的不同年龄组之间比较,部分差异有统计学意义(P<0.05),VD的NIHSS评分≥8分组较<8分组低,差异有统计学意义(P<0.05)。结论随年龄的增长,健康人群抗氧化能力逐步减弱,GR水平与首发缺血性脑卒中的发生密切相关,可能是缺血性脑卒中的危险因素,且VD水平与脑卒中的严重程度相关。 Objective To study the relationship between serum glutathione reductase,small dense low density lipoprotein and vitamin D in the new-onset of ischemic stroke,and to explore the clinical significance of oxidative index in the new-onset of ischemic stroke.Methods Totally 80 patients of the new-onset ischemic stroke were collected as the experimental group,80 cases of healthy subjects in the same period as the control group.We analyed serum glutathione reductase (GR),small dense low density Lipoprotein (sd- LDL) and vitamin D (VD) and other indicators of expression in ischemic stroke patients,and to evaluate the clinical value of each index to the severity of the patient.Results The GR level in the patients was lower than that in the healthy control group ( P <0.05).There was a significant part of difference between the different age groups of sd-LDL,GR and VD ( P <0.05).The NIHSS score ≥8 of VD was lower than that of <8 group ( P <0.05).Conclusion With the growth of age,the antioxidant ability of healthy people gradually weakened.GR level is closely related to the new-onset of ischemic stroke.It may be a risk factor for ischemic stroke,and VD levels are associated with the severity of stroke.
作者 李康 蒋波笛 朱蕾 何菊芳 王迪 孙彬 雷红 Li Kang;Jiang Bodi;Zhu Lei(Department of Clinical Laboratory,The 8th Medical Center of Chinese PLA General Hospital,Beijing 100091,China)
出处 《医学研究杂志》 2019年第7期28-30,58,共4页 Journal of Medical Research
基金 国家高技术研究发展计划(“863”计划)项目(2014AA022304)
关键词 缺血性脑卒中 氧化指标 危险因素 严重程度 Ischemic stroke Oxidative index Risk factors Severity
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