碳水化合物交换份法饮食干预对2型糖尿病合并高尿酸血症患者的疗效观察

Effects of Food Exchange Portion of Carbohydrate on Patients of Type 2 Diabetes Mellitus Combined Hyperuricemia

目的探讨碳水化合物交换份法对2型糖尿病(T2DM)合并高尿酸血症患者的临床疗效。方法2014年7月~2016年6月,选取笔者医院内分泌科及中美糖尿病中心和笔者医院平湖分院内分泌科收治的仅口服降糖药治疗T2DM合并高尿酸血症患者共140例,按照随机数字表法分为实验组和对照组。实验组进行碳水化合物交换份饮食干预(具体包括糖尿病合并高尿酸血症患者的饮食宣教以及基于碳水化合物交换份表配制的个体化糖尿病套餐),对照组实行常规的饮食指导。干预3个月,每周随访1次,每3个月测定1次干预前后空腹血糖(FPG)、餐后2h血糖、糖化血红蛋白(HbA1c)、血脂4项、血尿酸及体重等人体测量指标。结果经过综合干预后,实验组患者在FPG、餐后2h血糖、HbA1c、血脂4项和SUA较干预前均有明显的下降,差异有统计学意义(P<0.05);此外,与对照组比较,干预后实验组患者在FPG、餐后2h血糖、HbA1c、TG、TC及SUA的指标有明显的降低,且差异有统计学意义(P<0.05)。结论碳水化合物交换份法的饮食干预对T2DM合并高尿酸血症患者的治疗和控制中是有效的。

Objective To explore the effect of food exchange portion of carbohydrate on patients with type 2 diabetes mellitus(T2DM) combined hyperuricemia.Methods A total of 140 patients with T2DM complicated with hyperuricemia treated only with oral drug were selected from the department of endocrinology,the diabetes center of China and the United States of our hospital,and the department of endocrinology of Pinhu branch of our hospital from December 2014 to June 2016.Subjects were divided into experimental and control groups according to the random number table.The experimental group was intervened by the dietary intervention with carbohydrate exchange(specifically including dietary education of patients with T2DM complicated with hyperuricemia,and the preparation of a standardized diabetic meal based on the carbohydrate exchange table).Subjects in the control group received routine the routine dietary guidance.After 3 months of intervention,the patients were followed up once a week,and the fast blood glucose(FPG),2 hours postprandial blood glucose,hemoglobin A1c (HbA1c),triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),serum uric acid and body weight were measured every 3 months.Results After comprehensive intervention,FPG,2h postprandial blood glucose,HbA1c,TG,TC,HDL-C,LDL-C,and SUA in the experimental group were significantly decreased,and with statistically significant differences( P <0.05).In addition,compared with the control group,the indicators of FPG,2h postprandial blood glucose,HbA1c,TG,TC and SUA in the experimental group after intervention were significantly reduced,and the differences were statistically significant( P <0.05).Conclusion Dietary intervention with food exchange portion of carbohydrate is effective in the treatment and control of patients with T2DM complicated with hyperuricemia.