基于数据挖掘探讨《章次公医术经验集》胃病用药规律

Discussing the Law of Gastric Disease Drug Use Based on Data Mining in ZHANG Cigong Medical Experience Collection

目的探讨章次公先生治疗胃病方面的用药规律,为当代医家临床临证处方用药提供借鉴与参考。方法统计《章次公医术经验集》中胃病使用药物,并分别查出其药性、药味、功效及归经,运用Excel、Spss 22.0、Weka 3.8、Cytoscape 3.6.1对数据进行统计分析。结果章次公先生治疗胃病的高频药物是苦杏仁、茯苓、延胡索、当归、旋覆花、半夏、枳实等;其中药物功效归类以理气药居多,其次为化痰止咳平喘药及补虚药之类;药物药性多温、平;药物药味多辛、苦、甘;药物归经以脾经居多,其次为胃经、肺经及肝经。根据高频药物的关联规则分析,得到药对配伍规则如延胡索-苦杏仁配伍最多,其次是茯苓-苦杏仁、当归-苦杏仁、旋覆花-苦杏仁等;药组配伍规则以苦杏仁-延胡索-旋覆花最多,其次是苦杏仁-延胡索-当归、苦杏仁-旋覆花-延胡索、半夏-吴茱萸-茯苓等。结论数据挖掘结果发现章次公治疗胃病多用降气化痰、活血止痛、健脾行气等治法,对于当代医家在临床上辨证施治用药有着一定的指导意义。

Objective To explore the rule of ZHANG Cigong's treatment of gastric diseases, and to provide references for the clinical medication of contemporary Chinese physicians in clinical prescription and medication. Methods Statistical analysis of medicines used in gastric diseases in ZHANG Cigong Medical Experience Collection was carried out, and their medicinal properties, taste, efficacy and meridian attribution were found out respectively. The data were analyzed by Excel, SPSS 22.0, WEKA 3.8 and Cytoscape 3.6.1. Results ZHANG Cigong's high-frequency used medicines for gastric diseases were bitter Semen Armeniacae Amarum, Poria, Rhizoma Corydalis, Radix Angelicae Sinensis, FlosInulae, Rhizoma Pinelliae, Fructus Aurantii Immaturus, etc. Among them, the most effective drugs were Qi-regulating drugs, followed by phlegm-resolving, cough-relieving and asthma-relieving drugs, and deficiency-tonifying drugs. The medicinal properties of drugs were warm and flat, the medicinal flavor was pungent, bitter and sweet, and the spleen meridian was the dominant channel, followed by stomach meridian, lung meridian and liver meridian. According to the analysis of association rules of high frequency drugs, the compatibility rules of drug pairs such as Rhizoma Corydalis-bitter Semen Armeniacae Amarum were the most frequently appeared, followed by Poria-bitter Semen Armeniacae Amarum, Radix Angelicae Sinensis-bitter Semen Armeniacae Amarum, Flos Inulae-bitter Semen Armeniacae Amarum, etc. The compatibility rules of drug groups such as bitter Semen Armeniacae Amarum-Rhizoma Corydalis-FlosInulae were the most frequently used, followed by bitter Semen Armeniacae Amarum-FlosInulae-Rhizoma Corydalis, bitter Semen Armeniacae Amarum-Pinellia-Evodia-Poria-Flos Inulae-Rhizoma Corydalis, Rhizoma Pinelliae-Fructus Evodiae-Poria. Conclusion The results of data mining show that ZHANG Cigong often used the methods of descending Qi and phlegm, promoting blood circulation and relieving pain, invigorating spleen and promoting Qi in the treatment of gastric diseases, which had certain guiding significance for contemporary physicians in clinical differentiation of symptoms and syndromes.